arXiv:2602. 17911v3 Announce Type: replace-cross Abstract: Current biomedical question answering (QA) systems often assume that medical knowledge applies uniformly, yet real-world clinical reasoning is inherently conditional: nearly every decision depends on patient-specific factors such as comorbidities and contraindications.
arXiv:2608.22132v1 Announce Type: cross Abstract: Biomedical multi-hop question answering (QA) requires models to connect evidence across intermediate entities such as diseases, drugs, proteins, and...
The paper introduces a method for generating multilingual reasoning traces for medical question answering using large language models. It creates 500,000 reasoning traces in English, Italian, and Spanish by retrieving medical information from Wikipedia and applies them to MedQA and MedMCQA datasets extended into Italian and Spanish. The approach improves performance in both few‑shot in‑context learning and supervised fine‑tuning, achieving state‑of‑the‑art results for 8B‑parameter LLMs and releasing all resources for further research.
arXiv:2608.30556v1 Announce Type: new Abstract: Path-finding over knowledge graphs has become an effective way to ground LLM reasoning on multi-hop questions. However, biomedical QA introduces two di...
The paper introduces BRIE, a scalable framework that automatically creates question–answer pairs from longitudinal electronic health record notes, validated by nineteen clinicians. It offers a continuously maintainable benchmark for evaluating large language models in clinical settings, addressing limitations of manual, costly, and quickly outdated existing benchmarks. Experiments across nine LLMs and five inference strategies reveal that even state‑of‑the‑art systems often miss clinically important information, especially for synthesis‑heavy queries.
The paper introduces BRIE, a continuously maintainable benchmark for evaluating large language models (LLMs) in electronic health record (EHR) information retrieval. It presents a scalable framework that automatically generates question–answer pairs from longitudinal EHR notes, validated by nineteen clinicians. The benchmark allows assessment of multiple inference strategies and highlights that state‑of‑the‑art LLMs often miss clinically important information, especially when synthesis across documents is required.
BioMol-MQA is a new question‑answering dataset focused on polypharmacy that combines a multimodal knowledge graph—containing both text and molecular structure—with challenging questions designed to test large language models’ ability to retrieve and reason over this diverse information. The dataset highlights the limitations of current retrieval‑augmented generation systems, which typically handle only single‑modality text, by demonstrating that existing LLMs perform poorly unless provided with the necessary multimodal background data. This underscores the need for more robust RAG frameworks capable of integrating multiple data types for accurate responses.
arXiv:2607. 11891v1 Announce Type: cross Abstract: The deployment of large language models (LLMs) in specialized domains like medical diagnostics and financial advisory necessitates evaluating capabilities beyond general knowledge.
arXiv:2505. 02722v2 Announce Type: replace Abstract: Although large language models (LLMs) have demonstrated impressive reasoning capabilities across general domains, their effectiveness in real-world clinical practice remains limited.
arXiv:2610.08327v1 Announce Type: new Abstract: Large language models (LLMs) have shown promise in medical question answering and clinical reasoning, yet their improvement remains constrained by stat...
arXiv:2607. 19678v1 Announce Type: cross Abstract: AI-generated answers in high-stakes domains are often fluent but difficult to verify, especially when they contain multi-step reasoning rather than a single final answer.
MedRAGChecker is a claim-level verification framework designed for biomedical retrieval‑augmented generation (RAG). It decomposes generated answers into atomic claims and assesses each claim’s support by combining evidence‑grounded natural language inference with biomedical knowledge‑graph consistency signals. The aggregated claim decisions provide diagnostics that distinguish retrieval and generation failures, such as faithfulness, under‑evidence, contradiction, and safety‑critical errors, and the system is distilled into compact models for scalable evaluation.
arXiv:2603. 03292v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields.