Dose-PlanNet is a physics-guided 3D deep learning architecture that predicts radiotherapy dose distributions for prostate cancer. In a prospective trial, the model achieved target coverage comparable to clinical plans while slightly reducing target homogeneity, yet it significantly improved high‑dose organ‑at‑risk sparing. Automated plans met clinical acceptance criteria in 11 of 14 Moderate Hypofraction and 9 of 12 SBRT plans, demonstrating that physics-informed deep learning can accelerate radiotherapy workflows without compromising dosimetric quality.
By Ankit Bhattacharjee, Sougata Maity, Santam Chakraborty, Indranil Mallick
Dose-PlanNet is a physics-guided 3D deep learning model that predicts radiotherapy dose distributions for prostate cancer, aiming to automate complex treatment planning. In a prospective trial, the model achieved comparable target coverage while slightly reducing target homogeneity, yet it significantly improved high-dose organ‑at‑risk sparing. Automated plans met clinical acceptance criteria in most cases across both moderate hypofraction and stereotactic body radiation therapy arms.
The paper introduces a Mixture of Multicenter Experts (MoME) framework that leverages diverse clinical strategies to reduce bias in medical AI without sharing data across institutions. MoME integrates specialized expertise from multiple centers, improving generalizability and adaptability of a multimodal target volume delineation model for prostate cancer radiotherapy. The model, trained with few-shot imaging and clinical notes, outperformed baselines, especially in high inter‑center variability or limited data scenarios, and allows local customization without cross‑institutional data exchange.
By Yujin Oh, Sangjoon Park, Xiang Li, Pengfei Jin, Yi Wang, Jonathan Paly, Jason Efstathiou, Annie Chan, Jun Won Kim, Hwa Kyung Byun, Ik Jae Lee, Jaeho Cho, Chan Woo Wee, Peng Shu, Peilong Wang, Caiwen Jiang, Nathan Yu, Jason Holmes, Jong Chul Ye, Quanzheng Li, Wei Liu, Woong Sub Koom, Jin Sung Kim, Kyungsang Kim
arXiv:2603. 09448v2 Announce Type: replace-cross Abstract: Delineating the clinical target volume (CTV) in radiotherapy involves complex margins constrained by tumor location and anatomical barriers.
By Yoon Jo Kim, Wonyoung Cho, Jongmin Lee, Han Joo Chae, Hyunki Park, Sang Hoon Seo, Jae Myung Noh, Kyungmi Yang, Dongryul Oh, Jin Sung Kim
arXiv:2607. 02998v2 Announce Type: replace-cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.
By Max Van Puyvelde, Halil Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
arXiv:2607. 02998v1 Announce Type: cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.
By Max Van Puyvelde, Halil Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
arXiv:2606. 19460v1 Announce Type: cross Abstract: We introduce the first generative foundation model for chest radiograph synthesis trained from scratch at the billion-parameter scale.
By Fabio De Sousa Ribeiro, Emma A. M. Stanley, Charles Jones, Tian Xia, Dominic C. Marshall, Laurent Renard Trich\'e, Christopher V. Cosgriff, Panagiotis Dimitrakopoulos, Sotirios A. Tsaftaris, Ben Glocker
arXiv:2608. 03086v1 Announce Type: cross Abstract: Microwave ablation (MWA) is a promising minimally invasive treatment for liver tumors, but its therapeutic outcome strongly depends on patient-specific planning of antenna insertion trajectory, power, and treatment duration.
By Seonaeng Cho, Minjee Seo, Minju Seol, Juil Park, Joon Ho Kwon, Kyungho Yoon
arXiv:2602. 05387v2 Announce Type: replace-cross Abstract: MRI provides superior soft tissue contrast without ionizing radiation; however, the absence of electron density information limits its direct use for dose calculation.
By Zolnamar Dorjsembe, Hung-Yi Chen, Furen Xiao, Hsing-Kuo Pao
arXiv:2512. 08029v3 Announce Type: replace Abstract: Clinical decision-making in oncology requires predicting dynamic disease evolution, a task current static AI predictors cannot perform.
By Tianxingjian Ding, Yuanhao Zou, Chen Chen, Mubarak Shah, Yu Tian
arXiv:2512.08029v4 Announce Type: replace
Abstract: Clinical decision-making in oncology requires forecasting how disease evolves under treatment, yet most AI systems remain static predictors that ca...
By Tianxingjian Ding, Yuanhao Zou, Chen Chen, Mubarak Shah, Yu Tian
Generating CT volumes from MRI and CBCT can improve treatment planning in adaptive radiotherapy while avoiding additional radiation exposure. However, direct regression of CT intensities is challenged by the inherently high dynamic range and long-tailed distributions, thereby averaging out sparse yet clinically important structures.