arXiv Machine Learning

Biological Reasoning-Informed Regression for Interpretable Regulatory DNA Activity Prediction

arXiv:2606. 08147v1 Announce Type: cross Abstract: DNA cis-regulatory elements (CREs) such as enhancers control gene expression levels.

arXiv AI

1d ago

PertMind: Eliciting Emergent Biological Reasoning in LLM via Reinforcement Learning on Cellular Perturbation Data

arXiv:2608. 16419v1 Announce Type: cross Abstract: Large language models can describe mechanisms, yet scalable post-training still depends on costly, manually curated biological reasoning traces.

By Zhenchao Tang, Xiaogang Xu, Tianxu Lv, Jiahui Guan, Jiale Zhou, Haohuai He, Zhi Song, Hanbo Huang, Jiehui Huang, Jiafei Wu, Zhe Liu

llms reinforcement-learning

arXiv AI

Jun 2

Plausibility Is Not Prediction: Contrastive Evidence for LLM-Based Cellular Perturbation Reasoning

arXiv:2606. 01042v1 Announce Type: cross Abstract: Perturbation experiments are central to understanding cellular mechanisms, but remain costly and sparse, motivating prediction of gene expression responses for unobserved conditions.

By Xinyu Yuan, Xixian Liu, Jianan Zhao, Yashi Zhang, Hongyu Guo, Jian Tang

llms

arXiv AI

Jun 18

SciHorizon-GENE: Benchmarking LLM for Life Sciences Inference from Gene Knowledge to Functional Understanding

arXiv:2601. 12805v4 Announce Type: replace-cross Abstract: Large language models (LLMs) have shown growing promise in biomedical research, particularly for knowledge-driven interpretation tasks.

By Xiaohan Huang, Meng Xiao, Chuan Qin, Qingqing Long, Jinmiao Chen, Yuanchun Zhou, Hengshu Zhu

llms benchmarks safety

arXiv Machine Learning

Jun 5

SUPERNOVA: Eliciting General Reasoning in LLMs with Reinforcement Learning on Natural Instructions

arXiv:2604. 08477v2 Announce Type: replace-cross Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) has substantially improved reasoning in formal domains such as mathematics and code, but extending these gains beyond STEM remains challenging.

By Ashima Suvarna, Kendrick Phan, Mehrab Beikzadeh, Hritik Bansal, Saadia Gabriel

llms reinforcement-learning benchmarks

arXiv AI

Jul 7

RLIE: Rule Generation with Logistic Regression, Iterative Refinement, and Evaluation for Large Language Models

arXiv:2510. 19698v3 Announce Type: replace Abstract: Large Language Models (LLMs) can propose rules in natural language, sidestepping the need for a predefined predicate space in traditional rule learning.

By Yang Yang, Hua XU, Zhangyi Hu, Yutao Yue

llms

arXiv Machine Learning

Jun 2

OncoReason: Structuring Clinical Reasoning in LLMs for Robust and Interpretable Survival Prediction

arXiv:2510. 17532v2 Announce Type: replace-cross Abstract: Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data.

By Raghu Vamshi Hemadri, Geetha Krishna Guruju, Kristi Topollai, Anna Ewa Choromanska

llms nlp reinforcement-learning fine-tuning benchmarks safety

arXiv AI

Aug 10

bioMoR: Biology-Guided Mixture-of-Recursions for Effective Genomic Learning

arXiv:2608. 06727v1 Announce Type: new Abstract: Transformer models for high-dimensional omics analysis process thousands of genes or pathways, although only a subset requires deep computation.

By Koushik Howlader, Tirtho Roy, Md Tauhidul Islam, Wei Le

llms rag benchmarks safety

arXiv Machine Learning

Jul 22

PertReason: A Knowledge-Grounded Benchmark and Framework for Cell-State-Conditioned Mechanistic Reasoning of Perturbation Effects

arXiv:2607. 18777v1 Announce Type: new Abstract: Evaluating machine learning in scientific domains requires separating correct predictions from correct reasons under realistic distribution shifts.

By Dongkwan Kim, Yiming Gao, Yining Yang, Yang Shen

llms benchmarks

Hugging Face Trending Papers

Aug 7

bioMoR: Biology-Guided Mixture-of-Recursions for Effective Genomic Learning

Transformer models for high-dimensional omics analysis process thousands of genes or pathways, although only a subset requires deep computation. Mixture-of-Recursions (MoR) improves efficiency through adaptive token-choice or expert-choice routing.

llms rag benchmarks safety

arXiv AI

Jun 9

Knowledge Graphs and Reasoning LLMs for Finding Simple Yet Effective Transcriptomic Perturbation Predictors

arXiv:2606. 08816v1 Announce Type: cross Abstract: Predicting the effect of an unseen gene knockout perturbation on transcriptomic gene expression remains a highly challenging problem for virtual cell models.

By Jake Fawkes, Liam Hodgson, Jason Hartford

llms reinforcement-learning

Hugging Face Trending Papers

Jun 15

How Post-Training Shapes Biological Reasoning Models

Scientific reasoning models for biology combine language models with foundation models trained on multimodal biological data, including DNA, RNA, and proteins. These models are built through post-training, yet how each stage shapes reasoning and generalization remains poorly understood.

llms reinforcement-learning fine-tuning multimodal

arXiv AI

Jul 21

Enhancing LLMs' Clinical Reasoning with Real-World Data from a Nationwide Sepsis Registry

arXiv:2505. 02722v2 Announce Type: replace Abstract: Although large language models (LLMs) have demonstrated impressive reasoning capabilities across general domains, their effectiveness in real-world clinical practice remains limited.

By Junu Kim, Chaeeun Shim, Sungjin Park, Su Yeon Lee, Gee Young Suh, Chae-Man Lim, Seong Jin Choi, Song Mi Moon, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Sejoong Kim, Chami Im, Dong-Wan Kang, Yong Soo Kim, Hee-Joon Bae, Sung Yoon Lim, Han-Gil Jeong, Edward Choi

llms reinforcement-learning fine-tuning safety

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