arXiv:2606. 27752v1 Announce Type: new Abstract: Single-cell perturbation models can reduce costly wet-lab screening by predicting how cells respond transcriptionally to interventions.
By Dongxia Wu, Mingyu Li, Yuhui Zhang, Anurendra Kumar, Emma Lundberg, Serena Yeung-Levy, Emily B. Fox
Scientific reasoning models for biology combine language models with foundation models trained on multimodal biological data, including DNA, RNA, and proteins. These models are built through post-training, yet how each stage shapes reasoning and generalization remains poorly understood.
arXiv:2607. 18777v1 Announce Type: new Abstract: Evaluating machine learning in scientific domains requires separating correct predictions from correct reasons under realistic distribution shifts.
By Dongkwan Kim, Yiming Gao, Yining Yang, Yang Shen
arXiv:2606. 16517v1 Announce Type: new Abstract: Scientific reasoning models for biology combine language models with foundation models trained on multimodal biological data, including DNA, RNA, and proteins.
By Lukas Fesser, Hanlin Zhang, Michelle M. Li, Eric Wang, Bryan Perozzi, Shekoofeh Azizi, Sham M. Kakade, Marinka Zitnik
arXiv:2606. 01042v1 Announce Type: cross Abstract: Perturbation experiments are central to understanding cellular mechanisms, but remain costly and sparse, motivating prediction of gene expression responses for unobserved conditions.
By Xinyu Yuan, Xixian Liu, Jianan Zhao, Yashi Zhang, Hongyu Guo, Jian Tang
The paper introduces POISE, a reinforcement learning algorithm that uses a model’s internal states as a value estimator to reduce variance in reinforcement learning with verifiable rewards (RLVR). By employing a lightweight probe that reads internal signals during the forward pass, POISE predicts baselines online and uses a cross‑rollout construction to keep gradients unbiased. Experiments on Qwen3‑4B and OLMo3‑7B‑Instruct‑DPO across six domains show POISE outperforms existing RLVR baselines, offering more stable training and a value model that generalizes across tasks and scales with the policy.
By Yunho Choi, Jongwon Lim, Woojin Ahn, Minjae Oh, Jeonghoon Shim, Yohan Jo