arXiv:2606. 01042v1 Announce Type: cross Abstract: Perturbation experiments are central to understanding cellular mechanisms, but remain costly and sparse, motivating prediction of gene expression responses for unobserved conditions.
By Xinyu Yuan, Xixian Liu, Jianan Zhao, Yashi Zhang, Hongyu Guo, Jian Tang
The paper introduces OmicsBench, a new reasoning benchmark for multi‑omics sequences that includes 1,160 expert‑validated questions across DNA regulation, RNA processing, and protein function tasks, requiring traceable evidence chains. Evaluation of 17 large language models shows that scientific LLMs, while more accurate in classification, often lack valid evidence, suggesting shortcut learning. To address this, the authors propose tool‑augmented on‑policy distillation (TA‑OPD), a post‑training method that improves both evidence grounding and predictive performance across five Qwen3.5 models of varying sizes.
By Jie Ying, Zhefan Wang, Zihong Chen, Zhengqing Li, Jinzhe Li, Gang Li, Jian Liu, Fang Hu, Tao Luo, Zhonghang Yuan, Wanli Ouyang, Stan Z. Li, Fan Yang, Nanqing Dong
arXiv:2510. 17064v4 Announce Type: replace Abstract: Single-cell RNA sequencing has transformed our ability to identify diverse cell types and their transcriptomic signatures.
By Rongbin Li, Wenbo Chen, Zhao Li, Rodrigo Munoz-Castaneda, Jinbo Li, Neha S. Maurya, Arnav Solanki, Huan He, Hanwen Xing, Meaghan Ramlakhan, Zachary Wise, Nelson Johansen, Zhuhao Wu, Hua Xu, Michael Hawrylycz, W. Jim Zheng
arXiv:2607. 18777v1 Announce Type: new Abstract: Evaluating machine learning in scientific domains requires separating correct predictions from correct reasons under realistic distribution shifts.
By Dongkwan Kim, Yiming Gao, Yining Yang, Yang Shen
arXiv:2603. 11872v3 Announce Type: replace-cross Abstract: Translating single-cell RNA sequencing (scRNA-seq) data into mechanistic biological hypotheses remains a critical bottleneck, as agentic AI systems lack direct access to transcriptomic representations while expression foundation models remain opaque to natural language.
By Omar Coser
BioPhys-Bridge is a newly released benchmark dataset designed to evaluate language models on evidence‑grounded scientific reasoning within biophysical literature. Each of its 500 cases includes evidence blocks, stable IDs, quantitative values, units, equations, assumptions, mechanisms, and next‑step decisions, covering six biological domains and nine physical model families. The dataset enforces strict quality gates and has already been evaluated against several models, with DeepSeek‑V4‑Flash achieving the highest evidence‑ID F1 score of 0.360.
By Qingyang Xu