arXiv Machine Learning

Integrating Biological-Informed Recurrent Neural Networks for Glucose-Insulin Dynamics Modeling

arXiv:2503. 19158v3 Announce Type: replace Abstract: Type 1 Diabetes (T1D) management is a complex task due to many variability factors.

arXiv Machine Learning
Jun 8

GlucoFM-Bench: Benchmarking Time-Series Foundation Models for Blood Glucose Forecasting

arXiv:2606. 06881v1 Announce Type: new Abstract: Blood glucose forecasting models are foundational for modern diabetes management systems, as reliable short-term predictions can enable proactive interventions, support automated insulin delivery, and reduce the risk of hypo- and hyperglycemic events.

By Baiying Lu, Zhaohui Liang, Ryan Pontius, Shengpu Tang, Temiloluwa Prioleau
arXiv Machine Learning
Sep 11

Evaluating Time-Series Foundation Models and Multimodal Dietary Context for CGM Forecasting

The study evaluates time‑series foundation models for continuous glucose monitoring (CGM) forecasting across eight public datasets covering Type 1, Type 2, and non‑diabetes populations. Zero‑shot foundation models did not consistently beat strong task‑specific baselines, but lightweight fine‑tuning of models like Chronos‑Bolt improved root‑mean‑square error by up to 18% in both in‑distribution and out‑of‑distribution settings. Incorporating multimodal dietary context via CGMacros and a residual‑based fusion framework further reduced overall RMSE by ~3% and postprandial RMSE by ~15%, indicating that dietary signals add clinically meaningful value beyond CGM alone.

By Bowen Zhang, Hsiu-Wen Cheng, Hongyu Yang, Evie L. Shen, Joleen Vansomphone, Yuna Li, Kerry Zhou, Zitian Qu, Suning Zhao, Xiangning Deng, Hua Zhou, Jin J. Zhou
arXiv Machine Learning
Aug 27

GlucoFM: A Dual-Stream Foundation Model for Continuous Glucose Monitoring

GlucoFM is a lightweight foundation model for continuous glucose monitoring that aligns irregular CGM data to a 24‑hour grid and splits glucose dynamics into slow‑varying trend and short‑term deviation streams. Pre‑trained on over 109,000 hours of unlabeled recordings, it outperforms existing CGM‑specific models on seven phenotype‑classification tasks, improving average PR‑AUC by 4.1 points and enabling strong cross‑dataset transfer and few‑shot adaptation. When combined with meal, nutrition, and subject context, its frozen encoder delivers the lowest two‑hour postprandial glycemic response errors for trajectory, incremental AUC, peak rise, and peak timing metrics.

By Zechen Li, Keerthana Natarajan, Weizhi Zhang, Menglian Zhou, Simon A. Lee, Yuwei Zhang, Maxwell A. Xu, Zeinab Esmaeilpour, Flora D. Salim, Mark Malhotra, Lindsey Sunden, Shwetak Patel, Yuzhe Yang, Ahmed A. Metwally
arXiv Machine Learning
Jun 5

Evidence-Guided Neural Architecture Selection under Uncertainty for Subject-Specific Blood Glucose Forecasting

arXiv:2606. 05373v1 Announce Type: new Abstract: Reliable neural architecture selection is an open challenge in time-series forecasting under limited, noisy, and heterogeneous data, where standard heuristic architecture design and validation approaches fail to ensure accurate and reliable prediction and generalization.

By Md Azharul Islam, Dwyer Deighan, Tarunraj Singha, Danial Faghihi
arXiv Machine Learning
1d ago

Variability Aware Recursive Neural Network (VARNN): A Residual-Memory Model for Capturing Temporal Deviation in Sequence Regression Modeling

The paper introduces the Variability-Aware Recursive Neural Network (VARNN), a residual-aware architecture for supervised time-series regression that learns a nonlinear, vector-valued residual representation from recent prediction errors. VARNN conditions subsequent predictions on this learned residual-memory state, mapping scalar prediction innovations into a short-context representation. Experiments on nine datasets across energy, healthcare, and environmental domains show that VARNN achieves lower test MSE than static, lag-based, and sequence-model baselines, and ablations confirm that the learned residual memory improves predictive accuracy over direct scalar residual feedback.

By Haroon Gharwi, Yue Dai, Kai Shu