arXiv Machine Learning

Validated Synthetic Patient Generation for Small Longitudinal Cohorts: Coagulation Dynamics Across Pregnancy

arXiv:2604. 07557v2 Announce Type: replace Abstract: Small longitudinal cohorts, common in maternal health, rare diseases, and early-phase trials, limit computational modeling because enrollment is slow and the data are too sparse to train reliable models.

arXiv Machine Learning
Jul 21

Differentiable latent structure discovery for interpretable forecasting in clinical time series

arXiv:2604. 27967v2 Announce Type: replace Abstract: Background: We introduce StructGP, a continuous-time multi-task Gaussian process that couples process convolutions with differentiable structure learning to uncover a sparse, ordered directed acyclic graph (DAG) of inter-variable dependencies while preserving principled uncertainty.

By Ivan Lerner, Jean Feydy, Alexandre Kalimouttou, Anita Burgun, Francis Bach
arXiv Machine Learning
Oct 16

Predicting Live Birth After Fresh Embryo Transfer in IVF/ICSI: Differential ICM/Trophectoderm Morphology Encoding and a Hybrid Attention--Logistic Regression Ensemble

The study presents a curated dataset of 616 fresh embryo-transfer cycles and develops a Hybrid Attention Network (HAN) combined with logistic regression to predict live birth after IVF/ICSI. The HAN+LR ensemble achieved the best performance with an AUC‑ROC of 0.710, outperforming both individual components and other machine‑learning baselines. The differentially weighted trophectoderm morphology emerged as the most important predictor across models.

By Abdul Raheem Shahzad, Jinxin Chen, Ming Zhang, Juan Deng
arXiv Machine Learning
Jul 14

Imputation-free transformer learning enables robust Alzheimer's disease prediction and calibrated uncertainty quantification across heterogeneous clinical cohorts

arXiv:2607. 11656v1 Announce Type: cross Abstract: Accurate diagnostic classification and disease-severity prediction for Alzheimer's disease are hampered by the incompleteness and heterogeneity of real-world clinical data.

By Christelle Schneuwly Diaz, Narmina Baghirova, Duy-Thanh Vu, Duy-Cat Can, Gilles Allali, Philippe Ryvlin, Oliver Y. Ch\'en
arXiv AI
Sep 21

Diagnostic-Guided Longitudinal Modeling for Forecasting Retinal Atrophy Progression

The study proposes a diagnostic-guided approach to choose between stochastic and deterministic longitudinal imaging models based on whether inter-visit changes are driven by disease progression or acquisition variability. Applied to a large, heterogeneous Optos fundus autofluorescence archive, the diagnostic revealed weak time-dependent changes and limited benefit from stochastic models, leading to the development of the deterministic Temporal Retinal U‑Net (TRU). TRU outperformed other classical and deep‑learning comparators on image‑level and eye‑specific progression metrics across held‑out and independent zero‑shot transfer cohorts, though with slightly lower precision in a smaller cross‑vendor cohort.

By Liyin Chen, Souvick Mukherjee, Ines Maria De Carvalho Lains, Nazlee Zebardast, Mengyu Wang, Tobias Elze, Jason I. Comander