arXiv Machine Learning

Multi-label versus multi-class classification of blood cells and their aggregates in microfluidic channels

arXiv Machine Learning
Aug 17

CytoBERT: A Foundation Model for Cytometry Data

arXiv:2608. 14414v1 Announce Type: new Abstract: Cytometry measures the complex characteristics of single cells (e.

By Syed Abdul Haseeb Qadri, Bjarne C. Hiller, Felix Blanke, Vanja Sophie Cangalovic, Kutalm{\i}\c{s} Co\c{s}kun, Amin Mirzaei, Tom Siegl, Sebastian Bader, Thomas Kirste, Martin Becker
arXiv Machine Learning
Aug 12

Retrieval-Augmented Vision Foundation Models for Robust Leukemia Cell Classification across Multiple Microscopy Datasets

arXiv:2608. 10657v1 Announce Type: cross Abstract: Leukemia cell image classification is challenged by real-world domain shifts from acquisition, staining, illumination, and site protocols, causing single-dataset models to generalize poorly in real clinical scenarios.

By Carlos Zamora, Hiram Zuniga, Ulises Orozco-Rosas, Kenia Picos
arXiv Machine Learning
Jun 19

Computational Methods and Challenges in Cell-Free DNA Analysis for Multi-Cancer Early Detection

arXiv:2606. 20174v1 Announce Type: new Abstract: Cell-free DNA (cfDNA) is a promising avenue for non-invasive multicancer early detection (MCED), in that, it can enable multiple cancer detection simultaneously from a single blood draw, with particular sensitivity to cancers that currently lack established screening programs.

By Nicko Starkey, Marcin W. Wojewodzic, Krzysztof Rzecki
arXiv Machine Learning
Jul 7

LeukocyteCount: Automatic Identification and Counting for leukocytes using Deep Learning

arXiv:2607. 04486v1 Announce Type: new Abstract: Diagnosing and monitoring diseases frequently involves the analysis of human biological samples, with blood analysis being pivotal.

By Ahmed M. Sayed (Faculty of Computers and Artificial Intelligence, Helwan University, Cairo, Egypt), Sondos A. Refaat (Faculty of Computers and Artificial Intelligence, Helwan University, Cairo, Egypt), Abdallah M. Mostafa (Faculty of Computers and Artificial Intelligence, Helwan University, Cairo, Egypt), Mariam S. El-Rahmany (Faculty of Computers and Artificial Intelligence, Helwan University, Cairo, Egypt), Ensaf Hussein Mohamed (Faculty of Computers and Artificial Intelligence, Helwan University, Cairo, Egypt, School of Information Technology and Computer Science)
arXiv Machine Learning
Sep 17

Interpretable Multi-Instance Learning Enables Early Prediction of Key Molecular Alterations from Routine Flow Cytometry in Acute Myeloid Leukemia

An interpretable multi‑instance learning classifier based on a decision tree was developed to predict NPM1 and FLT3‑ITD mutations in acute myeloid leukemia using routine flow cytometry data. In cross‑validation on 197 patients, the model achieved AUROCs of 0.96 for NPM1 and 0.86 for FLT3‑ITD, outperforming a clinical baseline and matching deep learning methods. On an independent cohort of 161 patients, it maintained high performance with AUROCs of 0.90 and 0.82, and positive predictive values of 0.87 and 0.68, while cell‑level interpretation recovered known immunophenotypic signatures.

By Jonathan Legrand (IMB, MONC), Aguirre Mimoun (CHU Bordeaux), Baudouin Denis de Senneville (IMB, MONC), Audrey Bidet (CHU Bordeaux), Pierre-Yves Dumas (CHU Bordeaux, Inserm U1312 - BRIC), Christ\`ele Etchegaray (MONC, IMB)
arXiv AI
Sep 2

Semantic-Guided Multimodal Preprocessing for Vision Transformer-Based Clear Cell Renal Cell Carcinoma Grading

The paper introduces a semantic‑guided multimodal preprocessing technique that fuses nuclei classification maps with RGB histopathology images for Vision Transformer‑based grading of clear cell renal cell carcinoma. By concatenating classification map channels and applying multiplicative modulation, the method achieves a balanced accuracy of 0.916, markedly surpassing an RGB‑only baseline (0.707) and prior max‑voting approaches (0.427). Sensitivity analysis shows the 21‑percentage‑point improvement remains robust under simulated perturbations matching current nuclei classifier error rates, indicating effective use of imperfect nuclear‑level information.

By Fatemeh Javadian, Zhu Chen, Zahra Aminparast, Johannes Stegmaier