arXiv Machine Learning

Hierarchical Sparse Bayesian Multitask Learning for Disease Prediction in Pooled Microbiome Studies

This paper introduces a hierarchical Bayesian multitask learning model that assumes a shared sparsity structure across different binary classification tasks. The authors develop a variational inference algorithm for efficient posterior approximation and evaluate the method on synthetic data and pooled microbiome studies. Results show superior support recovery in synthetic experiments and robust, well‑calibrated predictions with informative taxa selection in microbiome classification.

arXiv Machine Learning
Jul 3

Structured Gaussian Processes for Uncertainty-Aware Classification of High-Dimensional, Small-Sampled Omics Data

arXiv:2607. 02103v1 Announce Type: cross Abstract: Classifying heterogeneous omics data remains a fundamental challenge in computational biology, particularly in high-dimensional, small-sample settings where nonlinear interactions dominate and class imbalance further complicates reliable prediction of minority phenotypes.

By Yue Zhang, Nandini Amit Gadhia, Georgios Karagiannis, Michalis Smyrnakis
arXiv AI
Aug 11

Biologically Informed Representation Learning for Robust Cross-Center Generalization of MALDI-TOF Mass Spectrometry

arXiv:2608. 08182v1 Announce Type: cross Abstract: Machine learning models for MALDI-TOF mass spectrometry have shown considerable promise for clinical microbiology tasks such as microbial identification and antimicrobial resistance prediction.

By Alejandro L. Garc\'ia-Navarro, Carlos Sevilla-Salcedo, Bel\'en Rodr\'iguez-S\'anchez, Vanessa G\'omez-Verdejo
arXiv Machine Learning
Jun 30

Friend or Foe

arXiv:2509. 00123v2 Announce Type: replace-cross Abstract: A fundamental challenge in microbial ecology is determining whether bacteria compete or cooperate in different environmental conditions.

By Oleksandr Cherednichenko, Josephine Solowiej-Wedderburn, Laura M. Carroll, Eric Libby
arXiv Machine Learning
Sep 1

Coarse composition suffices: tabular in-context learning for multi-activity antimicrobial peptide profiling

The study demonstrates that a simple, sequence-only approach using 330 interpretable descriptors and the TabPFN tabular foundation model can outperform complex multimodal deep learning methods for multi-label antimicrobial peptide activity prediction. On the ESCAPE benchmark (82,359 peptides, five labels), a label‑powerset TabPFN model achieved a mean average precision of 77.8%, surpassing the previous best of 72.1%. The approach also shows that predicted structure is unnecessary, that a small set of global physicochemical scalars can recover most performance, and that modeling label dependence benefits rare activities and informs assay prioritization.

By Raunak Kumar, Anuj Pal, Dhruvi Solanki, Parikshit Pareek, Juhi Singh, Jitin Singla