arXiv AI

LongAgent: History-Guided Agentic Search for Longitudinal Outcome Prediction

LongAgent is an agent-based method designed to extract predictive representations from heterogeneous longitudinal medical data. It autonomously searches over variable sets, temporal windows, and aggregation functions, using a history memory to guide exploration. On synthetic data, it achieves a mean prediction RMSE of 1.7376, outperforming the best non-agent baseline by 0.0151, and performs comparably to the best baseline on a real clinical dataset.

arXiv Computation and Language
Aug 28

BALMS: Benchmarking Agentic LLMs for Longitudinal Mental Health Sensing

BALMS is a benchmark for evaluating large language model (LLM) agents that analyze longitudinal wearable data to predict mental‑health wellbeing scores and generate evidence‑grounded rationales. It covers three real‑world datasets, two task families (score prediction and rationale generation), and tests five LLM backbones across open‑ and closed‑source paradigms. The study finds that zero‑shot agents rarely beat a simple mean baseline, and while chain‑of‑thought prompting helps reasoning, it does not ensure temporal grounding or numerical accuracy.

By Yu Yvonne Wu, Arvind Pillai, Yuliang Chen, Yuwei Zhang, Sudarshan Regmi, Tess Z. Griffin, Michael V. Heinz, Lisa A. Marsch, Nicholas C. Jacobson, Andrew Campbell
arXiv AI
Jun 11

Human-Guided Agentic AI for Multimodal Clinical Prediction: Lessons from the AgentDS Healthcare Benchmark

arXiv:2602. 19502v2 Announce Type: replace Abstract: Agentic AI systems are increasingly capable of autonomous data science workflows, yet clinical prediction tasks demand domain expertise that purely automated approaches struggle to provide.

By Lalitha Pranathi Pulavarthy, Raajitha Muthyala, Aravind V Kuruvikkattil, Zhenan Yin, Rashmita Kudamala, Saptarshi Purkayastha
arXiv AI
Aug 19

Foundation Agents Meet Agentic Deep Research: Evidence-Grounded Clinical Code Forecasting

The paper introduces ICD-Deepresearch, a workflow that combines foundation models for electronic health records (EHR) and language models with medical search and ICD dictionaries to forecast future ICD codes for upcoming clinical encounters. It evaluates candidate code transitions by linking patient evidence, external clinical relations, and exact code semantics within a fixed top‑K budget, using SparseEHR for initial priors, GPT‑5 for complementary forecasts, and a final selection step that validates, deduplicates, and ranks candidates. The method achieves patient‑averaged precision/recall of 24.60/35.09% on MIMIC‑III and 25.14/48.32% on MIMIC‑IV, with physicians rating 51–68% of its retrieved documents as useful, outperforming standalone GPT‑5 web search and Medical Deep Research.

By Junda Wang, Meysam Ghaffari, Akshat Choube, Mohsen Sharifi Renani, Hong Yu, Carlos Morato
arXiv Machine Learning
Aug 4

EHR2Path: Comprehensive Pathway-Level Modeling of Longitudinal Patient Trajectories from Multimodal Electronic Health Records

arXiv:2506. 04831v3 Announce Type: replace Abstract: Forecasting how a patient's condition is likely to evolve, including possible deterioration, recovery, treatment needs, and care transitions, could support more proactive and personalized care, but requires modeling heterogeneous and longitudinal electronic health record (EHR) data.

By Chantal Pellegrini, Ege \"Ozsoy, David Bani-Harouni, Matthias Keicher, Nassir Navab
arXiv AI
Aug 7

DoctorAgents: an agentic framework to iteratively refine AutoML pipeline for small clinical temporal data

arXiv:2608. 05375v1 Announce Type: new Abstract: Clinical machine learning (ML) has the potential to support high-stakes medical decision-making, but reliable deployment is often constrained by scarce, heterogeneous, and temporal complexity.

By Ruilin Wang, Bo-Hong Wang, Elizabeth Kourbatski, Jun Bai, Hegang Chen, Ziyang Song, Gilles Boire, Marie Hudson, Yue Li