The study presents an explainable multimodal deep‑learning framework that combines a 3D CNN for T1‑weighted MRI with a feedforward network for harmonized clinical and demographic data to diagnose Alzheimer’s disease. Using 6,479 ADNI records and 1,703 OASIS‑3 records, the authors compare various model configurations on three‑way and pairwise diagnostic tasks, finding that performance and explanations vary by task, modality, fusion strategy, and cohort. SHAP and Integrated Gradients consistently highlight the MMSE score as the most influential tabular feature, while CAM‑based explanations differ across model setups and cohorts, indicating that explainability is not a stable property under cohort shift.
By Yusuf Brima, Marcellin Atemkeng, Lakshmana Rao Namamula, Antoine Vacavant
arXiv:2607. 07091v1 Announce Type: cross Abstract: In longitudinal Alzheimer's disease (AD) diagnosis support, clinical and imaging information is often collected at irregular visits.
By Xinyue Du, Yibo Liu, Zhenglei Zhou, Xuancheng Yao, Weimin Zhong, Qiuhui Chen
In longitudinal Alzheimer's disease (AD) diagnosis support, clinical and imaging information is often collected at irregular visits. Integrating these multimodal observations may improve diagnostic assessment, but naive fusion can degrade performance when MRI is noisy or intermittently unavailable.
arXiv:2606. 11794v1 Announce Type: cross Abstract: Neurodegenerative diseases such as Alzheimer's disease (AD) require accurate and scalable tools for assessing disease severity, yet current clinical staging remains time-intensive and prone to variability.
By Boris-Stephan Rauchmann, Jonathan Laib, Buse Ercik, Robert Perneczky, Sergio Altares-L\'opez
The paper introduces MCNet, a neural network that assigns a Modality Contribution Score (MCS) to each patient, indicating how much structural MRI versus amyloid PET drives the diagnostic decision for Alzheimer’s disease. Across 327 ADNI-3 participants, MCNet achieved strong three‑class staging (AUC = 0.881) and the MCS showed a clear, statistically significant increase in PET dominance from cognitively normal to AD. The method was validated on an independent OASIS‑3 cohort and compared favorably to SHAP, suggesting it can guide personalized imaging and clinical trial decisions.
By Dawa Chyophel Lepcha, Aaliya Ali, Sophie A. Martin, Deepika Koundal, Pierrick Coupe, Shabbir Syed-Abdul
arXiv:2610.11394v1 Announce Type: new
Abstract: Multimodal Alzheimer's disease (AD) diagnosis benefits from integrating heterogeneous clinical, imaging, genomic, and biomarker evidence, but clinical...
By Chihun An, Ikbeom Jang
arXiv:2606. 17867v1 Announce Type: cross Abstract: Despite increasing adoption of multimodal approaches in Alzheimer's Disease (AD) research -- aimed at integrating molecular, structural, clinical, and genetic biomarkers to enhance disease characterization -- the relationships among these modalities remain poorly understood.
By Antonio Scardace, Daniele Rav\`i
arXiv:2606. 20037v1 Announce Type: new Abstract: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and a leading cause of death worldwide.
By Loukas Ilias, Anthi-Maria Vozinaki, Christos Ntanos, Dimitris Askounis
arXiv:2609.15888v1 Announce Type: cross
Abstract: Deep networks trained on structural MRI for Alzheimer's disease (AD) staging often reach reasonable accuracy while attending to anatomically irreleva...
By Paul-Gabriel Nicolae, Irina Georgiana Mocanu
arXiv:2606. 09671v1 Announce Type: cross Abstract: Alzheimer's disease (AD) progression is highly heterogeneous and is typically observed through sparse and irregular longitudinal data, posing challenges for prediction and personalised monitoring.
By Yinyu Huang, Yilin Zhang, Sofia Michopoulou, Christopher Kipps, Rahman Attar
M$^2$PFN is an end‑to‑end multimodal framework that extends the TabPFN in‑context learning engine to Alzheimer’s disease diagnosis by aligning 3D‑MRI and tabular features in a shared subspace. It performs differentiable inference through TabPFN’s transformer, back‑propagates gradients into the encoders, and incorporates a frozen tabular‑only prediction via a gated shortcut. On the ADNI cohort it achieves 65.55 % macro‑F1 and 82.21 % macro‑AUC, surpassing unimodal and multimodal baselines, and it generalizes to external cohorts without retraining.
By Lujia Zhong, Shuo Huang, Jianwei Zhang, Xinyu Nie, Yonggang Shi
arXiv:2607. 11656v1 Announce Type: cross Abstract: Accurate diagnostic classification and disease-severity prediction for Alzheimer's disease are hampered by the incompleteness and heterogeneity of real-world clinical data.
By Christelle Schneuwly Diaz, Narmina Baghirova, Duy-Thanh Vu, Duy-Cat Can, Gilles Allali, Philippe Ryvlin, Oliver Y. Ch\'en