arXiv:2607. 07091v1 Announce Type: cross Abstract: In longitudinal Alzheimer's disease (AD) diagnosis support, clinical and imaging information is often collected at irregular visits.
In longitudinal Alzheimer's disease (AD) diagnosis support, clinical and imaging information is often collected at irregular visits. Integrating these multimodal observations may improve diagnostic assessment, but naive fusion can degrade performance when MRI is noisy or intermittently unavailable.
The study presents an explainable multimodal deep‑learning framework that combines a 3D CNN for T1‑weighted MRI with a feedforward network for harmonized clinical and demographic data to diagnose Alzheimer’s disease. Using 6,479 ADNI records and 1,703 OASIS‑3 records, the authors compare various model configurations on three‑way and pairwise diagnostic tasks, finding that performance and explanations vary by task, modality, fusion strategy, and cohort. SHAP and Integrated Gradients consistently highlight the MMSE score as the most influential tabular feature, while CAM‑based explanations differ across model setups and cohorts, indicating that explainability is not a stable property under cohort shift.
arXiv:2512. 10966v3 Announce Type: replace-cross Abstract: Accurate and early diagnosis of Alzheimer's disease (AD) is critical for effective intervention and requires integrating complementary information from multimodal neuroimaging data.
arXiv:2606. 11794v1 Announce Type: cross Abstract: Neurodegenerative diseases such as Alzheimer's disease (AD) require accurate and scalable tools for assessing disease severity, yet current clinical staging remains time-intensive and prone to variability.
arXiv:2605.28397v2 Announce Type: replace Abstract: Predicting which people with mild cognitive impairment will develop dementia matters for early treatment. Yet structural imaging models have relied...
arXiv:2607. 01401v1 Announce Type: cross Abstract: INTRODUCTION: Accurate MRI-based identification of Alzheimer's disease (AD), mild cognitive impairment (MCI), and related dementias remains challenging because disease-related structural changes are often subtle and heterogeneous.
arXiv:2606. 17867v1 Announce Type: cross Abstract: Despite increasing adoption of multimodal approaches in Alzheimer's Disease (AD) research -- aimed at integrating molecular, structural, clinical, and genetic biomarkers to enhance disease characterization -- the relationships among these modalities remain poorly understood.
arXiv:2606. 20037v1 Announce Type: new Abstract: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and a leading cause of death worldwide.
MINT (Multimodal Imaging-to-Speech Knowledge Transfer) is a three-stage framework that transfers MRI-derived biomarkers to speech representations for early Alzheimer’s screening. An MRI teacher creates a compact embedding space for CN‑versus‑MCI classification, and a residual projection head aligns speech features to this space using a geometric loss, allowing imaging‑free inference. Experiments on ADNI‑4 show that aligned speech matches speech baselines, while multimodal fusion outperforms MRI alone, and ablations highlight dropout regularization and self‑supervised pretraining as key design choices.
arXiv:2609.15888v1 Announce Type: cross Abstract: Deep networks trained on structural MRI for Alzheimer's disease (AD) staging often reach reasonable accuracy while attending to anatomically irreleva...
The paper introduces MCNet, a neural network that assigns a Modality Contribution Score (MCS) to each patient, indicating how much structural MRI versus amyloid PET drives the diagnostic decision for Alzheimer’s disease. Across 327 ADNI-3 participants, MCNet achieved strong three‑class staging (AUC = 0.881) and the MCS showed a clear, statistically significant increase in PET dominance from cognitively normal to AD. The method was validated on an independent OASIS‑3 cohort and compared favorably to SHAP, suggesting it can guide personalized imaging and clinical trial decisions.
arXiv:2606. 19371v1 Announce Type: cross Abstract: Alzheimer's disease (AD) is a fatal disorder that destroys memory and cognitive skills in the elderly population.