The study presents an explainable multimodal deep‑learning framework that combines a 3D CNN for T1‑weighted MRI with a feedforward network for harmonized clinical and demographic data to diagnose Alzheimer’s disease. Using 6,479 ADNI records and 1,703 OASIS‑3 records, the authors compare various model configurations on three‑way and pairwise diagnostic tasks, finding that performance and explanations vary by task, modality, fusion strategy, and cohort. SHAP and Integrated Gradients consistently highlight the MMSE score as the most influential tabular feature, while CAM‑based explanations differ across model setups and cohorts, indicating that explainability is not a stable property under cohort shift.
By Yusuf Brima, Marcellin Atemkeng, Lakshmana Rao Namamula, Antoine Vacavant
The paper introduces a leakage‑controlled multimodal learning framework for diagnosing and predicting the progression of Alzheimer’s disease. It combines an adapted SFCN MRI encoder, four causal clinical Transformers, shared fusion, and task‑specific ODE‑GRU dynamics, with fine‑tuning and LoRA for MRI blocks. Across 2,649 subjects and 17,317 visits, the model achieves high AUROCs for diagnosis and progression, and demonstrates strong external validation on OASIS‑3 data.
By Akeem Temitope Otapo, Ghazaleh Khodabandelou, Zuheng Ming, Alice Othmani
arXiv:2606. 17867v1 Announce Type: cross Abstract: Despite increasing adoption of multimodal approaches in Alzheimer's Disease (AD) research -- aimed at integrating molecular, structural, clinical, and genetic biomarkers to enhance disease characterization -- the relationships among these modalities remain poorly understood.
By Antonio Scardace, Daniele Rav\`i
arXiv:2606. 19371v1 Announce Type: cross Abstract: Alzheimer's disease (AD) is a fatal disorder that destroys memory and cognitive skills in the elderly population.
By Long Doan, Branden Chen, Ethan Litton, Huan Huang, Jiajing Huang, Yixin Xie, Weihua Zhou, Nandakumar Narayanan, Chen Zhao
CoPoE is a new multimodal fusion framework for Alzheimer’s disease diagnosis that maps diverse clinical, imaging, genomic, and biomarker data into a structured latent space divided into four biological and clinical axes: genetic Risk, molecular Pathology, Neurodegeneration, and clinical Stage. Each available modality contributes a diagonal Gaussian expert, and a masked Product-of-Experts architecture fuses only the observed modalities, avoiding synthetic imputation. In extensive experiments on the ADNI dataset, CoPoE outperforms standard missing-modality fusion baselines, achieving higher AUROC, better calibration metrics, and retaining pathology signals even when certain modalities are missing.
By Chihun An, Ikbeom Jang
arXiv:2606. 20037v1 Announce Type: new Abstract: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and a leading cause of death worldwide.
By Loukas Ilias, Anthi-Maria Vozinaki, Christos Ntanos, Dimitris Askounis
arXiv:2607. 07091v1 Announce Type: cross Abstract: In longitudinal Alzheimer's disease (AD) diagnosis support, clinical and imaging information is often collected at irregular visits.
By Xinyue Du, Yibo Liu, Zhenglei Zhou, Xuancheng Yao, Weimin Zhong, Qiuhui Chen
In longitudinal Alzheimer's disease (AD) diagnosis support, clinical and imaging information is often collected at irregular visits. Integrating these multimodal observations may improve diagnostic assessment, but naive fusion can degrade performance when MRI is noisy or intermittently unavailable.
arXiv:2512. 10966v3 Announce Type: replace-cross Abstract: Accurate and early diagnosis of Alzheimer's disease (AD) is critical for effective intervention and requires integrating complementary information from multimodal neuroimaging data.
By Farica Zhuang, Shu Yang, Dinara Aliyeva, Zixuan Wen, Duy Duong-Tran, Christos Davatzikos, Tianlong Chen, Song Wang, Li Shen
The study presents a multimodal BrainAGE framework that fuses structural T1-weighted MRI with DeepCBV maps—vascular information synthesized from non‑contrast MRI—to estimate brain age more accurately. Using two separate 3D convolutional neural networks, the combined model achieved a mean absolute error of 3.95 years on cognitively normal controls, outperforming single‑modality models. Saliency analyses showed MRI highlighted white matter and cortical atrophy, while DeepCBV emphasized vascular‑rich regions, and the integrated approach revealed stronger differentiation between stable and progressive MCI, indicating sensitivity to early vascular changes.
By Jordan Jomsky, Zongyu Li, Kay C. Igwe, Yiren Zhang, Max Lashley, Tal Nuriel, Andrew Laine, Scott A. Small, Jia Guo, for the Frontotemporal Lobar Degeneration Neuroimaging Initiative, for the Alzheimer's Disease Neuroimaging Initiative
arXiv:2606. 11794v1 Announce Type: cross Abstract: Neurodegenerative diseases such as Alzheimer's disease (AD) require accurate and scalable tools for assessing disease severity, yet current clinical staging remains time-intensive and prone to variability.
By Boris-Stephan Rauchmann, Jonathan Laib, Buse Ercik, Robert Perneczky, Sergio Altares-L\'opez
arXiv:2607. 28687v1 Announce Type: cross Abstract: As populations age, cognitive decline from mild cognitive impairment (MCI) to dementia is a defining health challenge of the coming decades, yet routine assessment often misses its earliest signs.
By Mohammad Asif, Azizuddin Khan, Mohd Azam, Anurag Rajkumar Bombarde