OpenAI Blog

Biodefense in the Intelligence Age

An action plan for AI-powered biological resilience

arXiv AI
Sep 17

Human Resilience in the AI Era -- What Machines Can't Replace

The paper argues that the rapid pace of AI-driven change creates an adaptation gap, making human resilience a crucial capability for the AI era. Resilience is defined as the ability to absorb disruption while maintaining effective action and agency, and is examined at psychological, social, and organizational levels. The authors link resilience research with AI-in-the-loop experiments, showing that AI assistance can boost productivity, empathy, and calibrated reliance, and propose a socio‑technical agenda for education, workplace design, governance, and evaluation.

By Shaoshan Liu, Anina Schwarzenbach, Yiyu Shi
arXiv AI
Jun 19

Measuring Biological Capabilities and Risks of AI Agents

arXiv:2606. 19899v1 Announce Type: cross Abstract: This paper addresses a rapidly emerging policy challenge: how to generate and interpret credible evidence about the biological capabilities and risks of AI scientists, or agentic AI systems capable of autonomously or collaboratively performing multi-step scientific tasks.

By Patricia Paskov, Jeffrey Lee, Kyle Brady, Alyssa Worland
arXiv AI
Sep 23

Controlling risks of AI in chemical science with agents

arXiv:2312.06632v2 Announce Type: replace Abstract: Artificial intelligence is rapidly advancing scientific discovery, but this progress carries risks of misuse, such as the creation of harmful subst...

By Jiyan He, Haoxiang Guan, Weitao Feng, Yaosen Min, Jingwei Yi, Kunsheng Tang, Shuai Li, Jie Zhang, Kejiang Chen, Wenbo Zhou, Xing Xie, Weiming Zhang, Nenghai Yu, Shuxin Zheng
arXiv AI
Jul 22

BioSecBench-Refusal: A paired metric for performance and alignment in agentic biosecurity risk assessment

arXiv:2607. 05462v2 Announce Type: replace-cross Abstract: As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse.

By Edwin H. Wintermute, Harmon Bhasin, Christina M. Agapakis, Dianzhuo Wang, Evan Seeyave, Arjun Banerjee, Daniel Fulop, Matthew C. Watson, Adam J. Meyer, Sandrine Boissel, Jens H. Kuhn, Rishi Jain, Noah D. Taylor, Helena Shomar, Patrick M. Boyle, Kenny Workman