ClinAgent is a conversational system that uses a ReAct-based LLM agent to retrieve and synthesize clinical trial information from multiple sources such as ClinicalTrials.gov, PubMed, and a local dataset. The agent iteratively reasons over user queries, selects appropriate tools, and refines its actions to provide grounded, up-to-date responses in natural language across multi-turn interactions. Evaluation across three phases shows that DeepSeek (thinking mode) excels in planning quality while Gemini 3.0 Flash delivers the highest overall performance and expert ratings, demonstrating the promise of agentic AI for improving clinical trial data access.
By Antonino Vaccarella, Riccardo Cantini, Domenico Talia, Paolo Trunfio, Marianna Talia, Rosamaria Lappano, Marcello Maggiolini
arXiv:2606. 29746v1 Announce Type: new Abstract: Navigating the deluge of heterogeneous medical data, from academic literature (PubMed) to clinical guidelines (Web) and private knowledge bases, remains a critical bottleneck for evidence-based medicine.
By Maolin Liu, Fanyu Xu, Ruoqing Xu, Jiahang Zhang, Hao Wang, Rui Wang
Navigating the deluge of heterogeneous medical data, from academic literature (PubMed) to clinical guidelines (Web) and private knowledge bases, remains a critical bottleneck for evidence-based medicine. While commercial black-box tools lack transparency, standard open-source RAG implementations frequently suffer from reasoning drift when handling complex, long-tail queries.
arXiv:2607. 06452v1 Announce Type: cross Abstract: Biomedical question answering requires not only accurate extraction of information from scientific literature but also reliable integration of evidence across multiple documents.
By Taeyun Roh, Eunha Lee, Wonjune Jang, Sohyun Chung, Junha Jung, Jaewoo Kang
arXiv:2601. 04524v2 Announce Type: replace Abstract: Understanding biomedical experiments provides a foundation for downstream tasks, e.
By Haofei Hou, Shunyi Zhao, Fanxu Meng, Kairui Yang, Lecheng Ruan, Qining Wang
arXiv:2607. 20926v1 Announce Type: new Abstract: Scientific research involves complex information-seeking and reasoning workflows across heterogeneous sources.
By Yinhao Tang, Youqing Fang, Yanan Sun, Wenran Liu, Weiming Zhang, Bin Liu, Kuikun Liu, Wenwei Zhang, Kai Chen
The paper introduces an LLM-as-a-Judge framework for evaluating the outputs of an agentic drug discovery assistant, ChatInvent, deployed at AstraZeneca. It defines four quality dimensions—Completeness, Relevancy, Structural Clarity, and Scope Adherence—alongside deterministic Tool Call Correctness checks, and validates the judge against five expert annotators. After optimizing the best-performing judge with few-shot demonstrations, alignment with human majority votes improves from 0.80 to 0.86, and the framework reveals that informal question phrasing does not degrade output quality.
By Emma Granqvist, Roc\'io Mercado, Samuel Genheden
arXiv:2609.24620v1 Announce Type: new
Abstract: Answering epidemiological questions from real-world clinical data requires medical coding, schema-aware SQL, and validation of implicit choices about p...
By Angelo Ziletti, Leonardo D'Ambrosi, Melanie Tuchardt, Tim Kondziella
arXiv:2607. 12310v1 Announce Type: cross Abstract: While modern question answering (QA) systems excel on clean, schema-aligned corpora, real-world knowledge is rarely so neatly packaged.
By Michael Solodko, Steven Gong, Guangwei Yu, Satya Krishna Gorti, Jesse C. Cresswell, Victor Zhong
arXiv:2509. 23426v3 Announce Type: replace Abstract: AI scientists are emerging computational systems that serve as collaborative partners in discovery.
By Shanghua Gao, Richard Zhu, Pengwei Sui, Zhenglun Kong, Sufian Aldogom, Yepeng Huang, Ayush Noori, Reza Shamji, Krishna Parvataneni, Theodoros Tsiligkaridis, Marinka Zitnik
PathAnchor is a new scientific reasoning system that uses path-structured evidence workspaces instead of independent passages or concepts. It retrieves source-linked Material‑Sensor‑Signal‑System trajectories that preserve role, direction, and supporting evidence, and a controller uses read‑only tools to search, trace, and open exact evidence before producing a claim‑cited answer. In evaluations on 120 flexible‑sensor questions, PathAnchor achieved an 82.6% score, outperformed six other systems, and improved source recall, citation completeness, and reduced tool calls compared to unordered concept graphs.
By Qiuhui Chen, Jiafan Lu, Shuaimin Tang, Tao Dai, Suyuan Wang, Chenrui Ji, Zhenglei Zhou, Weimin Zhong
Nomad is an autonomous system designed to explore and discover insights within large data corpora. It builds an explicit Exploration Map to systematically traverse a domain, generating and testing hypotheses with an explorer agent that leverages document, web, and database searches. After verification, it produces cited reports and meta-reports, and its evaluation framework assesses trustworthiness, quality, and diversity, showing superior performance over baselines on UN, WHO, and arXiv datasets.
By Bokang Jia, Samta Kamboj, Satheesh Katipomu, Seung Hun Han, Neha Sengupta, Andrew Jackson