Synthetic healthcare data are widely proposed as privacy-preserving substitutes for real patient data, yet their evaluation remains dominated by statistical similarity and predictive performance that do not reflect clinical validity. We introduce a multi-dimensional evaluation framework grounded in epidemiology, assessing descriptive fidelity, clinical utility, and structural validity, corresponding to descriptive, predictive, and causal questions.
arXiv:2606. 06990v1 Announce Type: new Abstract: The generation of high-fidelity synthetic Electronic Health Records (EHR) is crucial for advancing medical research while preserving patient privacy.
By Jalen Jiang, Chufan Gao, Ethan Rasmussen, Stephen Z. Xie, Jimeng Sun
arXiv:2606. 07640v1 Announce Type: cross Abstract: This study investigates the trade-offs between fidelity, privacy, and utility in synthetic data generation under conditions of data scarcity and privacy sensitivity.
By Borja Arroyo Galende, Alejandro Almod\'ovar, Patricia A. Apell\'aniz, Juan Parras, Silvia Uribe, Santiago Zazo
arXiv:2604. 23904v3 Announce Type: replace-cross Abstract: Synthetic tabular data are often evaluated by distributional similarity, privacy distance, or train-on-synthetic-test-on-real predictive performance, but these criteria do not ensure validity for causal inference.
By Yichen Xu
arXiv:2607. 06163v1 Announce Type: cross Abstract: Foundation Models for Electronic Health Records (FEMRs) are pretrained on large-scale structured patient data, enabling them to convert longitudinal patient trajectories into generalizable representations for diverse clinical prediction tasks.
By Jie Huang, Pengfei Yin, Zihan Xu, Daniel Capurro, Mike Conway, Ting Dang
arXiv:2607. 19524v1 Announce Type: cross Abstract: Federated learning (FL) offers a promising approach to privacy-preserving clinical risk prediction, but its deployment remains limited by restricted data sharing, client heterogeneity, class imbalance, and the lack of realistic tabular electronic health record (EHR) benchmarks.
By Akarsh K Nair, Muhammad Arifur Rahman, Nicholas Shopland, Andy Burton, Jun He, Yuan Shen, David Baldwin, Emma O'Dowd, Amna Burzic, Mufti Mahmud, David J. Brown
arXiv:2509. 22352v3 Announce Type: replace Abstract: Survival analysis is a cornerstone of clinical research by modeling time-to-event outcomes such as metastasis, disease relapse, or patient death.
By Marie Brockschmidt, Maresa Schr\"oder, Stefan Feuerriegel
arXiv:2607. 02596v1 Announce Type: cross Abstract: Deep learning models for medical diagnosis frequently exhibit substantial performance disparities across sensitive subgroups (e.
By Xinyu Jia, Weidong Guo, Wangyuan Zhao, Yi Guo, Zeju Li, Yuanyuan Wang
arXiv:2606. 00563v1 Announce Type: cross Abstract: Selection bias is a common and often unavoidable aspect of real-world data that challenges the generalizability of machine learning models.
By Kara Liu, Maggie Wang, Russ B. Altman
arXiv:2608. 06265v1 Announce Type: new Abstract: Synthetic clinical benchmarks for enterprise AI agents can pass existing utility checks and still remain structurally unrealistic, especially in privacy-sensitive healthcare settings where operational data are hard to access.
By Omid Bazgir, Md Nasir, Jacob Hoffman, Yang Yang, Manu Agrawal, Anusua Trivedi, Vinay Rao Dandin, Chris Gibbons, Christine Swisher
arXiv:2606. 18518v1 Announce Type: cross Abstract: The development of medical AI is constrained by limited access to high-quality clinical data due to institutional silos and strict privacy regulations such as HIPAA and GDPR.
By Arshia Ilaty, Hossein Shirazi, Manasi Chitale, Kedar Hegde, Dhanalakshmi Ramesh, Rashmi S. Manjunath, Amir Rahmani, Hajar Homayouni
arXiv:2602. 12542v2 Announce Type: replace-cross Abstract: Deep learning models for clinical event prediction on electronic health records (EHR) often suffer performance degradation when deployed under different data distributions.
By Pengfei Hu, Chang Lu, Feifan Liu, Yue Ning