arXiv AI

A physics-informed foundation model for quantitative diffusion MRI

arXiv:2606. 00156v1 Announce Type: cross Abstract: Understanding the human brain requires access to its microscopic tissue architecture.

arXiv Machine Learning
Jun 16

Lesion-DDPM: Lesion-Enhanced 3D Diffusion for MS MRI Synthesis

arXiv:2606. 15457v1 Announce Type: cross Abstract: 3D FLAIR MRI is widely recommended as one of the standard MRI sequences for brain imaging in multiple sclerosis (MS), but publicly available MS datasets remain relatively small and vary across scanners, acquisition protocols, and lesion patterns.

By Weidong Zhang, Yongchan Jung, Shafayat Mowla Anik, Furen Xiao, Vasudevan Janarthanan, Enkhzaya Chuluunbaatar, Byeong Kil Lee, Jeeho Ryoo
arXiv Machine Learning
Aug 11

A continually expandable foundation model for brain MRI

arXiv:2608. 08319v1 Announce Type: cross Abstract: Brain magnetic resonance imaging (MRI) is central to neuroscience and clinical assessment, but models are commonly developed for individual diseases, populations or imaging protocols.

By Michail Mamalakis, Carmen Jimenez-Mesa, Yonghao Li, Hao Chen, Chao Li, Antonios Mamalakis, John Suckling, Richard Bethlehem, Stephen J. Price, Richard J. Gilbertson, Pietro Lio
arXiv AI
Jul 8

Reduced NEXI protocol for the quantification of human gray matter microstructure on the Connectome 2.0 scanner

arXiv:2509. 09513v3 Announce Type: replace-cross Abstract: Biophysical diffusion MRI models like Neurite Exchange Imaging (NEXI) are essential for probing gray matter microstructure, estimating compartment diffusivities, neurite fraction, and exchange time.

By Quentin Uhl, Tommaso Pavan, Julianna Gerold, Kwok-Shing Chan, Yohan Jun, Shohei Fujita, Aneri Bhatt, Yixin Ma, Qiaochu Wang, Hong-Hsi Lee, Susie Y. Huang, Berkin Bilgic, Ileana Jelescu
arXiv Machine Learning
Jun 18

Structural MRI Synthesis for Alzheimer's Disease via Conditional Diffusion on Anatomical Masks

arXiv:2606. 18354v1 Announce Type: cross Abstract: Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization.

By Muge Zhang, Muhammad Ali Khaliq, Jamal Alsakran, Byeong Kil Lee, Jeeho Ryoo
arXiv Computer Vision
Aug 21

4DLoG: Generative Modeling of Neurodegenerative Brain Anatomy with 4D Longitudinal Diffusion Model

arXiv:2604. 22700v2 Announce Type: replace Abstract: Modeling and predicting neurodegenerative disease progression from medical images remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning.

By Nivetha Jayakumar, Swakshar Deb, Bahram Jafrasteh, Qingyu Zhao, Miaomiao Zhang
arXiv Computer Vision
Sep 3

Progression as Latent Drift: Generative Forecasting of Slow-Evolving Pathologies

The paper introduces Latent Drift, a generative forecasting framework that predicts slow-evolving neurodegenerative disease progression by learning changes in a compressed semantic representation rather than full-resolution anatomy. It addresses two failure modes—identity collapse and continuous interpolation trap—by removing pixel-level identity from the prediction target and applying Finite Scalar Quantization to suppress high-frequency nuisance fluctuations. Experiments on longitudinal 3D brain MRI demonstrate that Latent Drift outperforms diffusion and autoregressive transformer baselines in both generative fidelity and clinically relevant metrics.

By Yuxiang Feng, Juncheng Wang, Chao Xu, Wenlong Hou, Huihan Wang, Yijie Qian, Yang Liu, Baigui Sun, Yong Liu, Shujun Wang
arXiv AI
Sep 16

MUMINS: Metadata-conditioned Uncertainty-aware Medical Image Next-state Synthesis

arXiv:2609.17169v1 Announce Type: cross Abstract: Forecasting anatomical changes such as tumor growth and neurodegeneration is a challenging generative vision task. Morphological evolution is subtle...

By Anna Oliveras, Roger Mar\'i, Rafael Redondo, Oriol Guardi\`a, Cynthia Ifeyinwa Ugwu, Ana Tost, Bhalaji Nagarajan, Carolina Migliorelli, Vicent Ribas, Petia Radeva
arXiv Computer Vision
6d ago

Cross-Modality Structural Guidance in 3D Latent Diffusion for Robust FLAIR Super-Resolution

The paper introduces MR‑DiffuSR, a 3‑D latent diffusion framework that uses high‑resolution T1w structural priors to guide super‑resolution of thick‑slice FLAIR MRI scans. By applying cross‑modality structural swin attention and a mixed‑scale degradation strategy, the method avoids hallucinations and remains robust across varying slice thicknesses. On ADNI datasets, MR‑DiffuSR outperforms CNN and 2‑D diffusion baselines, achieving high PSNR, SSIM, and low LPIPS, and maintains strong white‑matter hyperintensity segmentation performance even at 7 mm equivalent slice thickness.

By Haoyu Lan, Jiazhen Zhang, John Onofrey, Bino Varghese, Nasim Sheikh-Bahaei, Arthur W. Toga, Jeiran Choupan
arXiv AI
Jun 12

BrainDINO: A Brain MRI Foundation Model for Generalizable Clinical Representation Learning

arXiv:2604. 27277v3 Announce Type: replace-cross Abstract: Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data.

By Yizhou Wu, Shansong Wang, Yuheng Li, Mojtaba Safari, Mingzhe Hu, Chih-Wei Chang, Harini Veeraraghavan, Xiaofeng Yang
arXiv AI
Sep 18

Bridging Modalities on the Cortex: Surface-based MRI to PET Translation with a Diffusion Bridge

The paper introduces DB‑SUiT, a surface‑based diffusion bridge that translates cortical MRI to PET images directly on the cortical manifold. It employs a conditional spherical U‑shaped vision Transformer to capture multi‑scale surface features and long‑range dependencies while incorporating demographic and subcortical information. Evaluations on two dementia datasets show that the synthesized PET surfaces outperform MRI and PET volumes in automated classification and achieve high diagnostic accuracy in a blinded reader study.

By Yitong Li, Alexandra Samoylova, Fabian Bongratz, Timo Grimmer, Dennis M. Hedderich, Igor Yakushev, Christian Wachinger