arXiv:2412.15957v2 Announce Type: replace-cross
Abstract: The rapid development of large language models (LLMs) has transformed many industries, including healthcare. In practice, hospitals and patie...
By Ruize Shi, Hong Huang, Wei Zhou, Kehan Yin, Kai Zhao, Yun Zhao
arXiv:2607.13038v2 Announce Type: replace-cross
Abstract: Conversational AI can improve access to public health information, but public-facing healthcare applications require safeguards against inapp...
By Ben Torkian, Jun Zhou
arXiv:2609.07601v1 Announce Type: cross
Abstract: The application of large language models (LLMs) to personalized medical assistants has garnered growing interest. However, existing medical benchmark...
By Jun Xiang, Zhijie Bao, Rong Hu, Kaizhou Qin, Wei Chen, Zhongyu Wei
ClinAgent is a conversational system that uses a ReAct-based LLM agent to retrieve and synthesize clinical trial information from multiple sources such as ClinicalTrials.gov, PubMed, and a local dataset. The agent iteratively reasons over user queries, selects appropriate tools, and refines its actions to provide grounded, up-to-date responses in natural language across multi-turn interactions. Evaluation across three phases shows that DeepSeek (thinking mode) excels in planning quality while Gemini 3.0 Flash delivers the highest overall performance and expert ratings, demonstrating the promise of agentic AI for improving clinical trial data access.
By Antonino Vaccarella, Riccardo Cantini, Domenico Talia, Paolo Trunfio, Marianna Talia, Rosamaria Lappano, Marcello Maggiolini
arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
The article surveys how large language models (LLMs) are being applied to mental health, outlining a three‑phase evolution: Phase I uses LLMs as passive information tools and pattern recognizers for assessment; Phase II employs them as empathetic conversationalists for stateless, in‑the‑moment interactions; Phase III aims to create longitudinal, personalized companions that act as stateful cognitive agents. It systematically reviews core technologies, agent architectures (Profile, Memory, Reasoning, Planning), and the datasets and benchmarks that support this progression, offering a coherent narrative and roadmap for future research. The survey also provides a curated resource list at https://github.com/Emo-gml/Awesome-Mental-Health-LLMs.
By He Hu, Yucheng Zhou, Qianning Wang, Yingjian Zou, Chiyuan Ma, Juzheng Si, Jianzhuang Liu, Zitong Yu, Laizhong Cui, Fei Ma, Qi Tian
The paper presents an autonomous AI agent that combines ReAct and Retrieval-Augmented Generation to classify the severity of genetic diseases using 10,211 Human Phenotype Ontology terms. It applies ACMG severity guidelines and ACOG quality-of-life criteria, retrieving PubMed literature to produce interpretable reasoning chains and verify claims. The agent achieved 93.55% accuracy on phenotype-level classification and identified 3,283 autosomal recessive gene pairs with severe presentations, with 95.2% concordance in external validation.
By Tohid Ghasemnejad, Ahmadreza Argha, Mark Grosser, John Wang, Min Yang, Thantrira Porntaveetus, Tony Roscioli, Nigel H. Lovell, Mahmoud Aarabi, Hamid Alinejad-Rokny
arXiv:2609.00296v1 Announce Type: new
Abstract: Large language model (LLM) agents are increasingly proposed for healthcare tasks such as clinical documentation, evidence retrieval, patient messaging,...
By Junyi Yao, Baichuan Li, Zihao Zheng, Jiayu Long
arXiv:2607. 25485v1 Announce Type: new Abstract: Health AI is evolving from answering questions to agentic systems that converse with patients, reason about health records, and act on their behalf.
By Korosh Vatanparvar, Ashutosh Joshi, Maria Xenochristou, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Daniel Lopez-Martinez, Anchal Nema, Ramya Ganesan, Will Kimbrough, Alex Woody, Yadunandana Rao, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv:2607. 15314v1 Announce Type: new Abstract: Healthcare spans high-stakes communication, expert reasoning, and workflow execution, yet specialized LLMs that cover these use cases together remain limited.
By actAVA AI, :, Haolin Chen, Leon Qi, Steve Brown, Deon Metelski, Tao Xia, Joonyul Lee, Qixuan Wang, Kevin Riley, Frank Wang, Weiran Yao
arXiv:2609.15161v1 Announce Type: cross
Abstract: Large language model (LLM) driven multi-agent systems have shown promise in complex clinical reasoning, yet existing approaches rely on static strate...
By Dongsheng Shi, Yue Li, Xin Yi, Linlin Wang
The paper introduces SIC-Agents, a self‑improving framework designed to enhance simulation for pediatric serious illness communication (SIC) training. It presents two new benchmark suites—PitfallBench and DialogueBench—that assess simulators at both turn‑level and full‑dialogue levels, specifically addressing the unique challenges of multi‑party interactions and parental distress. Experiments demonstrate that SIC‑Agents surpasses static expert prompting, and the authors release the benchmarks for broader research use.
By Zihan Wang, Anita Marie Slominska, Rennie Bimman, Elizabeth Di Flumeri, Amanda Mayappo-Neeposh, Conall Francoeur, Tamara Ellen Carver, Xiao-Wen Chang, Doina Precup, Esin Darici Haritaoglu, Ismail Haritaoglu, Akshatha Arodi, Naomi Goloff