arXiv:2508. 14817v2 Announce Type: replace-cross Abstract: Objective: To evaluate whether retrieval-augmented generation (RAG) can serve as an efficient alternative to long-context prompting for clinical reasoning over electronic health records (EHRs).
By Skatje Myers, Dmitriy Dligach, Timothy A. Miller, Samantha Barr, James Landefeld, Yanjun Gao, Matthew Churpek, Anoop Mayampurath, Majid Afshar
arXiv:2607. 09322v1 Announce Type: new Abstract: In this work, we introduce LongMedBench, a real-world EHR-based benchmark for long-horizon clinical decision-making.
By Yanzhen Chen, Zihan Xu, Xiaocheng Zhang, Zhiting Fan, Weiqi Zhai, Hongxia Xu, Zuozhu Liu
The paper introduces BRIE, a continuously maintainable benchmark for evaluating large language models (LLMs) in electronic health record (EHR) information retrieval. It presents a scalable framework that automatically generates question–answer pairs from longitudinal EHR notes, validated by nineteen clinicians. The benchmark allows assessment of multiple inference strategies and highlights that state‑of‑the‑art LLMs often miss clinically important information, especially when synthesis across documents is required.
By Jordan L. Cahoon, Chloe O. Stanwyck, Sulaiman Somani, Philip Chung, Kevin R Keet, Kameron C. Black, Andrea T. Fisher, Sarita Khemani, Jerry Liu, Stephen Ma, Saloni K. Maharaj, Rita M. Pandya, Eduardo Perez-Guerrero, Priyanka Pillai, Lisa Shieh, David J. H. Wu, James Xie, James C. McAvoy, Teresa Nguyen, Jessica Tran, Lucy Yin, Bridget Lin, Alison Callahan, Jason A. Fries, Nigam H. Shah, Emily Alsentzer
The paper introduces BRIE, a scalable framework that automatically creates question–answer pairs from longitudinal electronic health record notes, validated by nineteen clinicians. It offers a continuously maintainable benchmark for evaluating large language models in clinical settings, addressing limitations of manual, costly, and quickly outdated existing benchmarks. Experiments across nine LLMs and five inference strategies reveal that even state‑of‑the‑art systems often miss clinically important information, especially for synthesis‑heavy queries.
arXiv:2609.39371v1 Announce Type: new
Abstract: In hospital workflows, electronic health records (EHRs) are often noisy, and may not contain the evidence needed to confirm events or measurements refe...
By Yitong Qiao, Yancheng Jin, Lei Liu, Yue Shen, Jian Wang, Jinjie Gu, Zhixuan Chu
arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv:2607. 13036v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for decision support in healthcare, but clinical evidence is often incomplete or evolving.
By Oriana Presacan, Andreea Grama, Larisa Irimin\u{a}, Alireza Nik, Jaya Ojha, Vajira Thambawita, Ciprian I. B\u{a}cil\u{a}, Bogdan Ionescu, Michael A. Riegler
arXiv:2609.18852v1 Announce Type: new
Abstract: Longitudinal electronic health records (EHRs) capture years of patient history across notes, codes, labs, and procedures, and contain evidence needed t...
By Fengnan Li, Heman Burre, Liwen Sun, Roshni Varma, Matthew M. Engelhard
EHR2Trace is a system that transforms electronic health records from multiple sources into a standardized, traceable event format suitable for training and evaluating patient world models and clinical agents. It links each event to its original record, separates the event time from the time the information became available, and distinguishes between medication orders, dispensing, and administration. The tool supports both OMOP and MEDS data models, includes automated validation, and was tested on three clinical datasets, converting 846.4 million events and detecting all injected faults.
By Xinye Yang, Yuli Wang, Cheng Ting Lin, Harrison Bai
arXiv:2608. 07796v1 Announce Type: new Abstract: Large language models perform strongly on medical knowledge benchmarks, but reliable clinical deployment requires agents to conduct defensible investigations over heterogeneous, longitudinal records: determining what evidence is needed, retrieving and reconciling structured and free-text data, grounding conclusions in verifiable evidence, and deferring cases that cannot be resolved reliably.
By Veronica Chatrath, Bryan Zhu, George Pu, Jingxuan Fan, Apaar Shanker, Varun Ursekar, Anahita Sharma, Jason Qin, Keqi Han, Soham Dinesh Tiwari, Soham Dan, Vijay Kalmath, Yuan Li, Daniel Yue Zhang, Chenguang Wang, Zainab Doctor, Zhijun Yin, Nigam H. Shah, Yuan Xue
arXiv:2609.00296v1 Announce Type: new
Abstract: Large language model (LLM) agents are increasingly proposed for healthcare tasks such as clinical documentation, evidence retrieval, patient messaging,...
By Junyi Yao, Baichuan Li, Zihao Zheng, Jiayu Long
arXiv:2606. 15735v1 Announce Type: cross Abstract: Discharge summaries are crucial clinical documents containing the context of a patient's overall hospital stay, and are routinely reviewed by medical experts for patient readmission, ongoing care, and diagnostic decision-making.
By Jiyoun Kim, Muhan Yeo, Eunhye Jang, Jeewon Yang, Hangyul Yoon, Su Ji Lee, Hee Jo Han, Hee-Jae Jung, Doyun Kwon, Jun young Lee, Jaehun Lee, Jung-Oh Lee, Sunjun Kweon, Jong Hak Moon, Daseul Kim, Minjae Cho, Edward Choi