arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
MindEval2 is a new evaluation framework for AI chatbots in mental health support, comprising Mental Health Quality Rubrics (MHQR) and the MindSim patient simulation harness. MHQR, developed with PhD-level psychologists, provides explicit, actionable criteria for assessing response quality, while MindSim offers realistic, longitudinal patient interactions with a memory component. The study evaluated 18 models, finding that although surface-level quality has improved, guidance calibration remains the main failure across all models.
By John Mendon\c{c}a, Daniel Tschernutter, Jos\'e Pombal, Areti Vassilopoulos, Catarina Botelho, Ignacio Sarasua, Maya D'Eon, Nuno Guerreiro, Ricardo Rei
arXiv:2508. 00923v3 Announce Type: replace Abstract: Large language models (LLMs) are increasingly used to answer health-related questions and support healthcare workflows, yet evidence for their safety still relies heavily on static benchmarks that can rapidly become obsolete or be optimized against.
By Jiazhen Pan (Cherise), Bailiang Jian (Cherise), Paul Hager (Cherise), Yundi Zhang (Cherise), Che Liu (Cherise), Friederike Jungmann (Cherise), Hongwei Bran Li (Cherise), Julian Canisius (Cherise), Chenyu You (Cherise), Junde Wu (Cherise), Jiayuan Zhu (Cherise), Fenglin Liu (Cherise), Yuyuan Liu (Cherise), Niklas Bubeck (Cherise), Moritz Knolle (Cherise), Chen (Cherise), Chen (Cherise), Christian Wachinger, Zhenyu Gong, Cheng Ouyang, Georgios Kaissis, Benedikt Wiestler, Daniel Rueckert
arXiv:2607. 08257v1 Announce Type: new Abstract: Large language models (LLMs) have shown strong performance on isolated psychiatric tasks, including dialogue, diagnosis, and treatment planning, yet existing benchmarks rarely simulate complete psychiatric clinical encounters.
By Yuming Yang, Xiao Sun, Yuanwei Zou, Zhengxiao Wu, Yun Chen, Jiang Zhong, Haoyang Zeng, Jingwang Huang, Kaiwen Wei
arXiv:2607. 02175v1 Announce Type: new Abstract: Multiple-choice medical benchmarks are increasingly saturated, and recent rubric-based evaluations such as HealthBench have shown that open-ended clinical performance is far from solved - its "Hard" subset top score remains 32%.
By Samiha A. Ismail, Fan X. Chen, Ali Merali
arXiv:2608. 12138v1 Announce Type: cross Abstract: General-purpose large language models (LLMs) have recently been reported to match or exceed specialized clinical AI tools on medical benchmarks, but such comparisons draw on a narrow set of systems and on benchmarks developed largely in high-income settings.
By Praveen Reddy, Charuta Mandke, Suvrankar Datta, Sarah Khan, Siddharth Reddy Anthireddy, Shitij Arora, Vishal Singh
arXiv:2609.38480v1 Announce Type: cross
Abstract: Most clinical benchmarks evaluate language models (LMs) on diagnosis using complete case descriptions. In clinical practice, however, patients presen...
By Xueting Fang, Zehui Li, Yang Yang, Camilla Giovino, Shubh K. Patel, Shailly Prajapati, Vallijah Subasri, Caihua Shan
Large language model assistants are being deployed to clinicians, but their readiness is judged mainly by benchmark scores that are based on examination questions or curated cases. This study analyzed 127,833 queries from 6,342 healthcare professionals across 35 specialties, finding that most requests were for documentation, administration, and knowledge retrieval, with a significant portion of queries unanswerable. When compared to 58 public benchmarks, the median benchmark lacked documentation requests and only shared 31% of the real task mix, indicating that current benchmarks poorly reflect actual clinical use.
By Krithik Vishwanath, Haitong Lin, Anton Alyakin, Jin Vivian Lee, D. Brock Hewitt, Jie J. Yao, William Robert Small, Hammad A. Khan, Cordelia Orillac, Aakaash Varma, Brandon Ye, Daniel Alexander Alber, Gustavo Stolovitzky, Batia Wiesenfeld, Oded Nov, Wei Wu, Kang Zhang, Yindalon Aphinyanaphongs, Tim Requarth, Eric Karl Oermann, The International Digital Twin Consortium in Healthcare, Medicine
arXiv:2510.25384v2 Announce Type: replace
Abstract: Large Language Models (LLMs) are promising tools for synthetic data generation in mental health. However, privacy policies and restrictions forced...
By Doan Nam Long Vu, Rui Tan, Lena Moench, Svenja Jule Francke, Daniel Woiwod, Florian Thomas-Odenthal, Sanna Stroth, Tilo Kircher, Christiane Hermann, Udo Dannlowski, Hamidreza Jamalabadi, Simone Balloccu, Shaoxiong Ji
arXiv:2609.15855v1 Announce Type: cross
Abstract: % !TEX root = ../main.tex People increasingly use large language models (LLMs) for mental health support, yet their safety in evolving, high-risk con...
By Laura M. Vowels, Matthew J. Vowels, Shivali Sharma, Apoorv Jha, Rehnuma Choudhury, Wasseem El Sarraj, Rachel Francois-Walcott, Aruba Hussain, Sarah Ingram, Angela Loulopoulou, Adva Segal, Elena Volkova
arXiv:2609.06080v1 Announce Type: cross
Abstract: Deeply phenotyped cohorts combine clinical, imaging, molecular, and wearable observations across timescales from seconds to years. This breadth can r...
By Gal Sapir, Alon Diament, Adva Wolf, Doron Yaya-Stupp, Dikla Gelbard Solodkin, Dana Azouri, Anat Etzion-Fuchs, Guy Lutsker, Eran Segal, Hagai Rossman
The paper introduces PrecepTron, a 32‑billion‑parameter language model fine‑tuned with low‑rank adaptation to evaluate clinical reasoning in large language models (LLMs) at a physician level. It also releases GRAND‑ROUNDS, a benchmark of 9,217 scored responses from 160 clinicians across seven studies. Using PrecepTron, the authors replicate key findings from major medical AI studies and explore new questions about LLM diagnostic accuracy, demonstrating that fine‑tuned models can provide consistent, scalable physician‑level scoring.
By Thomas A. Buckley, Zahir Kanjee, Peter G. Brodeur, Byron Crowe, Anthony M. Pettinato, Aashna P. Shah, Adrian D. Haimovich, Liam G. McCoy, Daniel Restrepo, Jason A. Freed, Ethan Goh, Jonathan H. Chen, Laura Zwaan, Katherine E. Goodman, Daniel J. Morgan, Raja-Elie E. Abdulnour, Adam Rodman, Arjun K. Manrai