arXiv AI By Laura M. Vowels, Matthew J. Vowels, Shivali Sharma, Apoorv Jha, Rehnuma Choudhury, Wasseem El Sarraj, Rachel Francois-Walcott, Aruba Hussain, Sarah Ingram, Angela Loulopoulou, Adva Segal, Elena Volkova

K-Bench: a clinically calibrated benchmark for evaluating large language models in high-risk mental health conversations

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arXiv AI
Jun 17

First, do NOHARM: towards clinically safe large language models

arXiv:2512. 01241v3 Announce Type: replace-cross Abstract: Large language models (LLMs) are routinely used by physicians and patients for medical advice, yet their clinical safety profiles remain poorly characterized.

By David Wu, Fateme Nateghi Haredasht, Saloni Kumar Maharaj, Priyank Jain, Jessica Tran, Matthew Gwiazdon, Arjun Rustagi, Jenelle Jindal, Jacob M. Koshy, Vinay Kadiyala, Anup Agarwal, Bassman Tappuni, Brianna French, Sirus Jesudasen, Christopher V. Cosgriff, Rebanta Chakraborty, Jillian Caldwell, Susan Ziolkowski, David J. Iberri, Robert Diep, Rahul S. Dalal, Kira L. Newman, Kristin Galetta, J. Carl Pallais, Nancy Wei, Kathleen M. Buchheit, David I. Hong, Vartan Pahalyants, Ernest Y. Lee, Allen Shih, Tamara B. Kaplan, Vishnu Ravi, Sarita Khemani, Thomas A. Buckley, April S. Liang, Daniel Shirvani, Advait Patil, Nicholas Marshall, Kanav Chopra, Joel Koh, Adi Badhwar, Anastasia Perez, Austin J. Schoeffler, Mahbuba Tusty, Chase M. Walton, Liam G. McCoy, David J. H. Wu, Yingjie Weng, Sumant Ranji, Kevin Schulman, Nigam H. Shah, Jason Hom, Arnold Milstein, Arjun K. Manrai, Adam Rodman, Jonathan H. Chen, Ethan Goh
arXiv AI
Aug 24

When Vocabulary Comprehension Fails Clinical Reasoning: Evaluating Therapy Bots' Safety Risks for Generation Alpha

The paper evaluates the safety of conversational AI therapy bots for Generation Alpha, revealing that while these models understand 76‑82% of youth‑specific vocabulary, they correctly assess clinical risk only 64‑72% of the time, creating a significant vocabulary‑comprehension gap. Six failure patterns—such as sarcasm masking, minimization acceptance, and semantic drift—were identified, with compounded errors leading to a 94% miss rate when three or more patterns co‑occur. The authors estimate 146,880 missed crises annually and recommend mandatory human‑in‑the‑loop systems, quarterly youth‑specific validation, transparent performance disclosure, and regulatory oversight for youth‑facing mental health AI.

By Manisha Mehta, Virendra Mehta
arXiv AI
Jun 2

A Multi-Domain Red Teaming Framework for Safety, Robustness, and Fairness Evaluation of Medical Large Language Models

arXiv:2606. 00027v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly deployed across healthcare, yet existing benchmarks fail to capture model behavior under adversarial or ethically complex conditions common in clinical practice.

By Andrei Marian Feier, Veysel Kocaman, Yigit Gul, Ahmet Korkmaz, Alexander Thomas, Aleksei Zakharov, Jay Gil, Mehmet Butgul, David Talby
arXiv AI
Jul 9

SycoEval-EM: Sycophancy Evaluation of Large Language Models in Simulated Clinical Encounters for Emergency Care

arXiv:2601. 16529v4 Announce Type: replace Abstract: Large language models (LLMs) deployed in clinical decision support may acquiesce to patient requests for care that conflicts with evidence-based guidelines.

By Dongshen Peng, Yi Wang, Austin Schoeffler, Sun-ha Hong, Brian Suffoletto, David Kim, Carl Preiksaitis, Christian Rose