AI safety and alignment

Alignment, interpretability, red-teaming, bias and privacy: the research on what these systems do when they misbehave.

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Simon Willison
Sep 29

Quoting Anthropic Frontier Red Team

The article reports that on a set of 100 randomly selected tasks from an internal Binary Exploitation benchmark, GLM‑5.3 achieved full control‑flow hijacks in 4% of the trials, while Claude Mythos Preview did so in 6%. Both models outperform earlier versions such as Claude Opus 4.6 and GLM‑5.2, which succeeded in none of the trials. This indicates that a significant threshold in adversarial exploitation capabilities has been crossed by the newer models.

Towards Data Science
Sep 29

How to Design Architectural Guardrails Around AI Agents

The article "How to Design Architectural Guardrails Around AI Agents" discusses essential agent design patterns that data engineers should understand. It emphasizes the importance of establishing clear architectural boundaries to ensure AI agents operate safely and effectively within larger systems. The post was originally published on Towards Data Science.

By Thuwarakesh Murallie
arXiv Machine Learning
Sep 29

Improving Molecular-Morphology Contrastive Pretraining using Deep-Learning-based Morphology Profiles

The paper presents MoCoP v2, an enhanced contrastive pretraining method that aligns small molecule embeddings with deep‑learning‑derived cell morphology profiles. By replacing CellProfiler fingerprints with richer image‑encoded features, the new embeddings better capture how molecules alter cell morphology, leading to improved QSAR, toxicity, ADME, and activity predictions. Performance scales log‑linearly with training data size, indicating further gains with larger datasets.

By Jie Li, Kathryn E. Kirchoff, Dante A. Pertusi, Zhizhuo Zhang
arXiv Machine Learning
Sep 29

GyroNovo: Error-Guided Fragment Imputation with Mass-Aware Attention for \textit{De Novo} Peptide Sequencing

GyroNovo is a new framework for de novo peptide sequencing that improves fragment imputation by guiding the process with decoder errors observed during training. It introduces mass-aware attention using rotary embeddings to encode pairwise mass differences between spectral peaks, and creates easy and hard augmented views of spectra to train the decoder under varying corruption levels. Experiments on NovoBench demonstrate significant gains, with about 9 percentage points higher peptide-level precision and 7 percentage points higher amino-acid-level precision compared to the state-of-the-art baseline.

By Abdellah El Mekki, Laks V. S. Lakshmanan, Muhammad Abdul-Mageed
arXiv Machine Learning
Sep 29

Counterfactual Online Conformal Prediction Under Adaptive Logging

The paper addresses the failure of online conformal prediction when predictions influence actions that determine which outcomes are used for calibration. It introduces Propensity-Weighted Online Conformal Prediction (PW‑OCP), an inverse‑propensity‑weighted recursion that debiases calibration, and a doubly robust variant (DR‑OCP) that further reduces bias. Experiments on synthetic decision tasks, open bandit data, and financial rebalancing demonstrate that PW‑OCP and DR‑OCP improve counterfactual coverage and downstream regret while preserving prediction‑set sharpness.

By Xinyu Qiao, Yichen Lin, Kaihong Ji, Xue Wang, Tao Yao