Pix2Rep-v2 is a self‑supervised learning framework that learns pixel‑ and voxel‑level representations for dense medical imaging tasks, using a redundancy‑reduction objective and equivariance principles to scale to 3D and wide field‑of‑view data. The method is evaluated on four datasets across multiple modalities, tasks, and backbones, demonstrating higher data‑efficiency in few‑shot scenarios and competitive performance, such as a +9.3 Dice point improvement in one‑shot segmentation on the M&Ms‑2 dataset. An in‑context dense prototype approach is also proposed, eliminating the need for downstream training.
By S. Sifaoui, E. Angelini, S. Toupin, T. Pezel, L. Le Folgoc
DALE-CT introduces depth‑aware 2D slice encoders that learn an anatomical world model of chest CT scans without 3D or positional supervision. By sampling self‑supervised views across a physical $z$‑axis slab, the encoder captures how anatomy changes between neighboring slices, enabling it to recover slice ordering and distinguish slices by anatomy alone. The model, trained on a large 287k‑scan corpus, achieves state‑of‑the‑art performance on CT‑RATE and is released with full code and evaluation tools.
By Evan W. Damron, Mahmut S. Gokmen, Mitchell A. Klusty, Caroline N. Leach, Emily B. Collier, V. K. Cody Bumgardner
arXiv:2609.25850v1 Announce Type: new
Abstract: Deep learning performance generally improves with increasing training data, yet this scaling is fundamentally constrained by annotation cost in large-s...
By Xiaofei Du, Lei Zhang, Shuyu Yan, Manning Wang, Zhijian Song
The paper presents a 3D foundation model for light sheet fluorescence microscopy (LSM) that is pretrained on a large curated set of 3D images from various organisms, stains, and imaging protocols. By jointly optimizing for masked reconstruction and image‑text alignment, the model learns transferable volumetric representations that dramatically reduce the need for annotated data. The pretrained backbone enables efficient few‑shot adaptation to downstream tasks such as segmentation, classification, and deblurring, consistently outperforming baselines according to standard metrics and expert evaluation.
By Adina Scheinfeld, Haotan Zhang, Shang Mu, Rudolf L. M. van Herten, Lucas Stoffl, Ali Erturk, Zhuhao Wu, Johannes C. Paetzold
arXiv:2606. 03888v1 Announce Type: cross Abstract: Self-supervised learning has enabled large-scale pre-training on 2D natural images, producing general-purpose visual representations that transfer effectively across tasks.
By Ioannis Gatopoulos, Nicolas K\"anzig, Sebastian Ot\'alora, Fei Tang
DART is a new RGB‑D pretraining method for surgical vision foundation models that incorporates pseudo‑labeled depth maps as a pixel‑space reconstruction target during training. By adding a depth reconstruction head to DINOv2’s masked iBOT framework, DART improves representation quality without affecting downstream RGB‑only fine‑tuning or inference. Across eight surgical benchmarks—including segmentation, depth estimation, and image‑level recognition—DART outperforms both natural‑image and in‑domain baselines, demonstrating that geometric pseudo‑labels can strengthen foundation model pretraining without extra labels or inference cost.
By John J. Han, Adam Schmidt, Muhammad Abdullah Jamal, Jie Ying Wu, Omid Mohareri