arXiv Computer Vision By Hyeongyeol Lim, Hongjun Yoon, Eunjin Jang, Daeky Jeong, Won June Cho, Hwamin Lee

SheafStain: Sheaf-Theoretic Schr\"odinger Bridge for Spatially and Biologically Coherent Virtual Staining

Read the original on arXiv Computer Vision →

SheafStain introduces a sheaf-theoretic Schr"odinger Bridge framework to improve virtual staining of gigapixel whole-slide images. By treating Vision Foundation Model features as sheaf-like sections, it integrates class and patch tokens to enforce spatial and biological coherence, mitigating patch-boundary artifacts. The method is evaluated on HER2, ER, PR, and Ki‑67 stains, outperforming six prior approaches on stitched 1024 × 1024 outputs.

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