Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths globally, with approximately 1,926,425 new cases and 904,019 deaths reported in 2022. Accurate histologic grading plays a critical role in prognosis and treatment planning for colorectal adenocarcinoma.
arXiv:2607. 03253v1 Announce Type: cross Abstract: As hematoxylin & eosin (H&E) staining constitutes the primary entry point in routine diagnostic workflows, computer-aided diagnosis from whole-slide H&E images is of particular clinical relevance.
The paper presents an automated segmentation pipeline for whole‑slide histopathology images of colorectal cancer, labeling tumor grades 1‑3 and normal mucosa. It employs dense prediction transformers with multiple encoder backbones, overlapping patches, test‑time augmentation, and an adaptive augmentation policy guided by large language models. The approach, combined with soft‑voting ensembles and post‑processing refinements, raises the F1 score from 62.92 to 69.84 on a colorectal cancer grade dataset.
arXiv:2608. 15915v1 Announce Type: cross Abstract: Lung cancer remains the leading cause of cancer-related mortality worldwide, while histopathological diagnosis is often affected by inter-observer variability and the substantial workload associated with manual slide examination.
arXiv:2602. 04819v5 Announce Type: replace-cross Abstract: Accurate risk stratification of precancerous polyps during routine colonoscopy screening is a key strategy to reduce the incidence of colorectal cancer (CRC).
RACR-MIL is a weakly‑supervised method for grading squamous cell carcinoma (SCC) from whole‑slide images, using an attention‑based multiple‑instance learning framework. It introduces a hybrid WSI graph to capture local tissue context and non‑local phenotypic dependencies, and applies rank‑ordering constraints on attention to prioritize higher‑grade tumor regions, mirroring pathologists’ diagnostic reasoning. The approach achieves state‑of‑the‑art performance, improving SCC grading accuracy by 3–9% over existing methods and up to 10% in tumor localization, and a pilot study showed pathologists reported increased grading efficiency in 60% of cases.
arXiv:2602. 02124v2 Announce Type: replace-cross Abstract: Drug-induced toxicity is a leading cause of preclinical and early-clinical failure, making early detection critical.
arXiv:2608. 07543v1 Announce Type: cross Abstract: Background and Study Aims: Accurate optical diagnosis of colorectal polyps guides resection strategy and surveillance, with multimodal large language models (MLLMs) showing potential for image-based diagnosis.
The paper introduces AMPLIFAI, the first public dataset of multiphase abdominal CT scans annotated with LI-RADS categories and segmented for three key LI-RADS features: arterial phase hyperenhancement, washout, and enhancing capsule. It outlines the dataset’s composition, curation process, and annotation pipeline following the Datasheets for Datasets format to promote transparency and reproducibility. The dataset aims to support the development of AI models for automated hepatocellular carcinoma diagnosis using the biopsy‑free, imaging‑based LI‑RADs framework.
The paper introduces CoPath, a lightweight framework for diagnosing peripheral neuroblastic tumors (pNTs) from whole-slide images. CoPath combines CoHisNet, a multi‑scale feature‑fusion network that replaces traditional MLPs with Kolmogorov‑Arnold Network layers for efficient nonlinear modeling, and PathVote, which aggregates patch‑level predictions using pathology‑informed priors. Experiments on a private pNT cohort and the public BreakHis dataset show that CoPath matches or surpasses existing classifiers while reducing computational complexity.
arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.
arXiv:2604.27697v2 Announce Type: replace-cross Abstract: Peritoneal metastases (PM) are staged using the surgically determined Peritoneal Cancer Index (sPCI), which requires invasive laparoscopic as...