arXiv AI By Ian Diks, Zhen Yang, Arjun Banerjee, Tim Proctor, Kenny Workman

scBench-Long: Verifiable Benchmarking of Long-Horizon Single-Cell Biology

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arXiv:2606. 26563v1 Announce Type: cross Abstract: Single-cell studies require analysts to convert raw measurements into specific biological claims through multi-step workflows and integration of metadata, assay context, and auxiliary evidence.

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arXiv AI
Aug 3

ELISA: An Interpretable Hybrid Generative AI Agent for Expression-Grounded Discovery in Single-Cell Genomics

arXiv:2603. 11872v3 Announce Type: replace-cross Abstract: Translating single-cell RNA sequencing (scRNA-seq) data into mechanistic biological hypotheses remains a critical bottleneck, as agentic AI systems lack direct access to transcriptomic representations while expression foundation models remain opaque to natural language.

By Omar Coser
arXiv Machine Learning
Jun 2

HR-VILAGE-3K3M: A Human Respiratory Viral Immunization Longitudinal Gene Expression Dataset for Systems Immunity

arXiv:2505. 14725v2 Announce Type: replace-cross Abstract: Respiratory viral infections pose a global health burden, yet the cellular immune mechanisms underlying protection and pathology remain unclear.

By Xuejun Sun, Yiran Song, Xiaochen Zhou, Ruilie Cai, Yu Zhang, Xinyi Li, Rui Peng, Jialiu Xie, Yuanyuan Yan, Muyao Tang, Prem Lakshmanane, Baiming Zou, James S. Hagood, Raymond J. Pickles, Didong Li, Fei Zou, Xiaojing Zheng
arXiv Machine Learning
Jun 10

OncoTraj: a public benchmark for longitudinal resistance prediction in EGFR-mutant non-small-cell lung cancer on osimertinib

arXiv:2606. 11144v1 Announce Type: new Abstract: Resistance to first-line osimertinib in EGFR-mutant non-small-cell lung cancer (NSCLC) is the canonical example of predictable clonal evolution under therapeutic pressure, yet no public benchmark exists for training or evaluating computational models on the corresponding longitudinal patient trajectories.

By Abhijoy Sarkar, Aarchi Singh Thakur
arXiv AI
Jun 30

Data-Efficient Multimodal Alignment for Histopathology-based Molecular Prediction

arXiv:2606. 29949v1 Announce Type: cross Abstract: H&E-stained whole-slide images offer cohort-scale availability and rich spatial context but lack molecular specificity, whereas bulk RNA-seq provides transcriptome-wide resolution at high cost with limited archival availability.

By Dominik Winter, Dominik Vonficht, Lo\"ic Le Bescond, Christian Gebbe, Marco Rosati, Richard J. Chen, Markus Schick, Ross Stewart, Nicolas Brieu