Safe to Stop? Risk-Constrained Stopping for Sequential Clinical Diagnosis Agents

The paper introduces Cros, a risk‑constrained stopping layer for sequential clinical diagnosis agents that determines when to stop testing and make a diagnosis. Cros combines state‑wise error ranking, policy design on disjoint development splits, and exact tests of selective diagnostic error to provide finite‑sample guarantees. On a MIMIC‑derived abdominal‑pain benchmark, Cros achieves higher state‑error AUROC and lower selective error rates compared to baseline stopping methods, though its performance varies across development resplits.

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• agents
• benchmarks
• safety