arXiv:2602. 04119v2 Announce Type: replace Abstract: The application of generative models for experimental drug discovery campaigns is severely limited by the difficulty of designing molecules de novo that can be synthesized in practice.
By Hyeonah Kim, Minsu Kim, Celine Roget, Dionessa Biton, Louis Vaillancourt, Yves V. Brun, Yoshua Bengio, Alex Hernandez-Garcia
arXiv:2606. 07610v1 Announce Type: cross Abstract: State-of-the-art GRPO-style methods for speech-aware large language model post-training suffer from coarse credit assignment, broadcasting the same terminal-reward advantage to every token in a response.
By Argyrios Gerogiannis, Yekaterina Yegorova, Mark Hasegawa-Johnson, Venugopal V. Veeravalli
arXiv:2602. 21565v3 Announce Type: replace Abstract: Generative Flow Networks (GFlowNets) learn to sample diverse candidates in proportion to a reward function, making them well-suited for scientific discovery, where exploring multiple promising solutions is crucial.
By Seokwon Yoon, Youngbin Choi, Seunghyuk Cho, Seungbeom Lee, MoonJeong Park, Dongwoo Kim
arXiv:2606. 16847v1 Announce Type: cross Abstract: Diffusion Large Language Models (dLLMs) offer a promising avenue for parallel generation but face a trade-off between decoding speed and quality.
By Yizhen Yao, Qinglin Zhu, Runcong Zhao, Xiangxiang Dai, Yanzheng Xiang, Yulan He, Lin Gui
arXiv:2509. 26405v2 Announce Type: replace Abstract: We introduce InVirtuoGen, a discrete flow generative model for fragmented SMILES for de novo and fragment-constrained generation, and target-property/lead optimization of small molecules.
By Benno Kaech, Luis Wyss, Karsten Borgwardt, Gianvito Grasso
arXiv:2605. 01729v2 Announce Type: replace Abstract: Generative Flow Networks (GFlowNets) learn to sample states proportional to an unnormalized reward.
By Zengxiang Lei, Ananth Shreekumar, Jonathan Rosenthal, Ruoyu Song, Alvaro A. Cardenas, Daniel J. Fremont, Dongyan Xu, Satish Ukkusuri, Z. Berkay Celik