Pretraining and Distillation Matter More Than Architecture Family for Label-Free Single-Cell Classification
Read the original on arXiv Computer Vision →The Flow has not summarised this story yet — read it at arXiv Computer Vision.
The Flow has not summarised this story yet — read it at arXiv Computer Vision.
The study evaluates self‑supervised learning (SSL) models pretrained on ImageNet‑1k and the Human Protein Atlas (HPA) Field‑of‑View (FOV) for protein localization in microscopy images. DINO‑based Vision Transformer backbones pretrained on either dataset transfer well to the OpenCell dataset, achieving strong performance even without fine‑tuning and improving further when fine‑tuned (0.704 ± 0.027 macro F1 on 17 classes). At the single‑cell level, the HPA‑pretrained model outperforms others in k‑nearest‑neighbor classification across all neighborhood sizes (macro F1 ≥ 0.515).
arXiv:2607. 14703v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become the main paradigm for whole-slide image (WSI) analysis in computational pathology.
Vision Transformers underperform convolutional networks when training data is scarce, and distilling convolutional inductive biases from a CNN teacher is an effective remedy that leaves the deployed model unchanged. General-purpose feature distillation, however, transfers little in this setting.
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