The study evaluates self‑supervised learning (SSL) models pretrained on ImageNet‑1k and the Human Protein Atlas (HPA) Field‑of‑View (FOV) for protein localization in microscopy images. DINO‑based Vision Transformer backbones pretrained on either dataset transfer well to the OpenCell dataset, achieving strong performance even without fine‑tuning and improving further when fine‑tuned (0.704 ± 0.027 macro F1 on 17 classes). At the single‑cell level, the HPA‑pretrained model outperforms others in k‑nearest‑neighbor classification across all neighborhood sizes (macro F1 ≥ 0.515).
arXiv:2610.31848v1 Announce Type: new Abstract: Imaging Flow Cytometry (IFC) generates large multispectral datasets, yet the need for expert annotations bottlenecks the development of supervised deep...
arXiv:2609.09863v1 Announce Type: new Abstract: Choosing a deep learning architecture for label-free single-cell classification remains an open question, with microscopy benchmarks reporting conflict...
arXiv:2407.03463v2 Announce Type: replace-cross Abstract: In the realm of self-supervised learning (SSL), conventional wisdom has gravitated towards the utility of massive, general domain datasets fo...
arXiv:2603. 18846v3 Announce Type: replace-cross Abstract: Foundation models are used to extract transferable representations from large amounts of unlabeled data, typically via self-supervised learning (SSL).
The paper introduces HAND, a biologically-inspired activation function that incorporates homeostasis, accelerating nonlinearity, and divisive normalization to act as an inductive bias in deep neural networks. Experiments on image classification show that using HAND allows a ConvNeXt-tiny model to reach ImageNet1k accuracy in 25 epochs versus 200 epochs for the baseline, and yields larger accuracy gains on long-tailed and reduced-data settings. The authors report that HAND does not degrade generalisation on common corruptions and can improve the model’s ability to reject unknown classes, with benefits observed across multiple CNN architectures and datasets.
arXiv:2410.21582v4 Announce Type: replace-cross Abstract: Large-scale pretrained models are widely leveraged as foundations for learning new specialized tasks via fine-tuning, with the goal of mainta...
arXiv:2603. 13377v2 Announce Type: replace-cross Abstract: Representation learning has driven major advances in natural image analysis by enabling models to acquire high-level semantic features.
arXiv:2606. 23964v1 Announce Type: new Abstract: Self-supervised learning in fluorescence microscopy often relies on 2D projections, despite the inherently three-dimensional nature of cells.
arXiv:2505.07675v3 Announce Type: replace-cross Abstract: Semi-supervised learning (SSL) has emerged as a practical solution for addressing data scarcity challenges by leveraging unlabeled data. Rece...
arXiv:2607. 14703v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become the main paradigm for whole-slide image (WSI) analysis in computational pathology.
arXiv:2608.07632v2 Announce Type: replace-cross Abstract: Image-based profiling captures rich phenotypic signatures for drug discovery and functional genomics. Large public datasets like JUMP Cell Pa...
The paper investigates whether pretrained image models can generalize to unseen datasets by clustering their embeddings. Using encoders trained only on ImageNet‑1k, both supervised and self‑supervised, the authors evaluate clustering performance on out‑of‑domain images. They find that supervised encoders perform better within the training domain, while self‑supervised encoders excel far outside it, and that fine‑tuning self‑supervised models reverses this trend. Additionally, the study shows that the silhouette score in UMAP‑reduced space correlates strongly with clustering accuracy, offering a proxy metric when labels are unavailable.