The study evaluates self‑supervised learning (SSL) models pretrained on ImageNet‑1k and the Human Protein Atlas (HPA) Field‑of‑View (FOV) for protein localization in microscopy images. DINO‑based Vision Transformer backbones pretrained on either dataset transfer well to the OpenCell dataset, achieving strong performance even without fine‑tuning and improving further when fine‑tuned (0.704 ± 0.027 macro F1 on 17 classes). At the single‑cell level, the HPA‑pretrained model outperforms others in k‑nearest‑neighbor classification across all neighborhood sizes (macro F1 ≥ 0.515).
arXiv:2609.09863v1 Announce Type: new Abstract: Choosing a deep learning architecture for label-free single-cell classification remains an open question, with microscopy benchmarks reporting conflict...
arXiv:2407.03463v2 Announce Type: replace-cross Abstract: In the realm of self-supervised learning (SSL), conventional wisdom has gravitated towards the utility of massive, general domain datasets fo...
arXiv:2603. 18846v3 Announce Type: replace-cross Abstract: Foundation models are used to extract transferable representations from large amounts of unlabeled data, typically via self-supervised learning (SSL).
arXiv:2603. 13377v2 Announce Type: replace-cross Abstract: Representation learning has driven major advances in natural image analysis by enabling models to acquire high-level semantic features.
arXiv:2606. 23964v1 Announce Type: new Abstract: Self-supervised learning in fluorescence microscopy often relies on 2D projections, despite the inherently three-dimensional nature of cells.
arXiv:2607. 14703v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become the main paradigm for whole-slide image (WSI) analysis in computational pathology.
arXiv:2608.07632v2 Announce Type: replace-cross Abstract: Image-based profiling captures rich phenotypic signatures for drug discovery and functional genomics. Large public datasets like JUMP Cell Pa...
The paper investigates whether pretrained image models can generalize to unseen datasets by clustering their embeddings. Using encoders trained only on ImageNet‑1k, both supervised and self‑supervised, the authors evaluate clustering performance on out‑of‑domain images. They find that supervised encoders perform better within the training domain, while self‑supervised encoders excel far outside it, and that fine‑tuning self‑supervised models reverses this trend. Additionally, the study shows that the silhouette score in UMAP‑reduced space correlates strongly with clustering accuracy, offering a proxy metric when labels are unavailable.
arXiv:2606. 07633v1 Announce Type: cross Abstract: Accurate classification of nuclei subtypes in histopathology images is critical for downstream tasks including tumor grading, immune infiltrate quantification, and prognosis prediction.
Pix2Rep-v2 is a self‑supervised learning framework that learns pixel‑ and voxel‑level representations for dense medical imaging tasks, using a redundancy‑reduction objective and equivariance principles to scale to 3D and wide field‑of‑view data. The method is evaluated on four datasets across multiple modalities, tasks, and backbones, demonstrating higher data‑efficiency in few‑shot scenarios and competitive performance, such as a +9.3 Dice point improvement in one‑shot segmentation on the M&Ms‑2 dataset. An in‑context dense prototype approach is also proposed, eliminating the need for downstream training.
arXiv:2608.21427v1 Announce Type: new Abstract: Tuberculosis (TB) is one of the most common and dangerous bacterial ailments. Every year, it causes a large number of deaths worldwide. Although many d...
arXiv:2606. 17471v1 Announce Type: new Abstract: Traditional CPU, GPU, and NPU architectures are increasingly limited by the von Neumann bottleneck.