The study developed a Vision Transformer-based deep learning model with uncertainty estimation to detect glaucoma from colour fundus photographs across multi‑ethnic populations, including those with high myopia. Using 56,483 images for training, the model achieved an internal AUROC of 98.7% and maintained high performance (AUROC 86.4–99.6%) on 16 external datasets from eight countries. In high‑myopia eyes, the model outperformed ophthalmologists and matched specialists when full clinical data were available.
By Raghavan Lavanya, Yangqin Feng, Ten Cheer Quek, Quan V. Hoang, Linda Yi-Chieh Poon, Jost B. Jonas, Ya Xing Wang, Vinay Nangia, Jin Wook Jeoung, Sehie Park, SoYeon Kim, Benjamin Y Xu, Sreenidhi Iyengar Munimadugu, Paul Mitchell, Gerald Liew, Yanin Suwan, Jirayu Hong-amata, Sahil Thakur, Monisha E Nongipur, Tina Wong, Rahat Husain, Ng Si Rui, Yamon Syn, Phey Feng Lo, Nicholas Tan Yi Qiang, Shaista Hussain, Xiaofeng Lei, Zhi Da Soh, Marco Yu, Haslina Hamzah, Zizhou Wang, Yan Wang, Liangli Zhen, Xinxing Xu, Tien-Yin Wong, Tin Aung, Rachel S Chong, Yong Liu, Ching-Yu Cheng
The study presents a cost‑sensitive XGBoost model that predicts ESBL‑producing Enterobacteriaceae at the time of culture ordering using 45 pre‑culture EHR features from 132,955 cultures across 12 hospitals. At 90% sensitivity the model achieves a 95.8% negative predictive value, potentially allowing carbapenem‑sparing therapy in non‑ICU settings while avoiding unnecessary broad‑spectrum treatment for 307 out of every 1,000 cultures, at the expense of 14 missed ESBL cases per 1,000. SHAP analysis highlights prior ESBL colonization as the strongest predictor, with minimal performance loss when socioeconomic deprivation features are omitted, supporting equitable bedside deployment.
By Aravind V. Kuruvikkattil, Lalitha Pranathi Pulavarthy, Rashmita Kudamala, Saptarshi Purkayastha