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CellPath-Bench is a new benchmark that evaluates whole-slide cellular representations in pathology foundation models (PFMs) by using 25 spatially aligned H&E–Xenium tissue sections from 11 organs and over 7 million cells. It introduces metrics such as Cell Representation Advantage (CRA) and Cell Representation Transferability (CRT) to assess how well frozen PFMs encode cell-type information and generalize across tissue sections, datasets, and organs. The benchmark was applied to 30 PFMs, revealing significant model-dependent differences in cell-type decodability and cross-domain generalization, and offers a standardized framework for auditing cellular information in frozen PFM representations.
arXiv:2607. 22712v1 Announce Type: cross Abstract: Single-cell light microscopy images have become an important data source for characterizing cell phenotypes, but their complexity and heterogeneity pose challenges to high-throughput automated analysis.
arXiv:2608. 09636v1 Announce Type: cross Abstract: Accurate 3D neuron segmentation in fluorescence microscopy is critical for neuroscience.
Catena is an open‑source, developer‑centric software suite designed to streamline large‑scale connectomics from electron microscopy data. It integrates modules for 3D neuron and organelle segmentation, synapse detection, microtubule tracking, and neurotransmitter inference into composable, chunk‑wise pipelines that are fully documented and extensible. The suite includes pretrained machine learning models, containerized runtimes, and shareable components to reduce compute and ground‑truth data needs while ensuring reproducible, scalable processing across workstations and clusters.
Tracking neurite morphology over time helps characterize structural changes during neuronal development and deterioration, but long-term time-lapse imaging is resource-intensive and difficult to scale...
arXiv:2609.23990v1 Announce Type: new Abstract: Tracking neurite morphology over time helps characterize structural changes during neuronal development and deterioration, but long-term time-lapse ima...