Active surveillance (AS) is the preferred strategy for favorable-risk prostate cancer, yet current protocols rely on scheduled repeat biopsies, most of which reveal no progression and are unnecessary. Existing risk-stratification tools operate on single time-point imaging or depend on explicit lesion segmentation, limiting their ability to capture longitudinal change and excluding patients without an MRI-visible lesion.
The paper introduces ANT, a test‑time adaptation framework that improves prostate cancer detection in micro‑ultrasound by performing a segmentation‑guided adaptation. ANT aligns a pretrained detection encoder to the target domain’s prostate anatomy using pseudo‑masks from a frozen segmentation network, thereby correcting domain‑specific feature drift while preserving cancer‑discriminative features. In a leave‑one‑center‑out evaluation, ANT raises mean AUC by 2.9% at the biopsy‑core level and 3.6% at the patient level compared to no adaptation, outperforming existing TTA baselines.
By Obed Korshie Dzikunu, Mohammad Mahdi Abootorabi, Mohamed Harmanani, Paul F. R. Wilson, Emma Willis, Ferdinand Luger, Adam Kinnaird, Brian Wodlinger, Parvin Mousavi, Purang Abolmaesumi
arXiv:2605. 23995v4 Announce Type: replace-cross Abstract: Self-supervised learning (SSL) is increasingly used in medical image analysis to reduce dependence on costly expert annotations by learning transferable representations from unlabeled data.
By Chathura Wimalasiri, Kishor Nandakishor, Marimuthu Palaniswami
arXiv:2510.14383v4 Announce Type: replace
Abstract: Accurate brain tumor segmentation is significant for clinical diagnosis and treatment but remains challenging due to tumor heterogeneity. Mamba-bas...
By Danish Ali, Ajmal Mian, Naveed Akhtar, Ghulam Mubashar Hassan
The paper investigates combining a domain‑specific self‑supervised task—voxel‑level brain age prediction—with a general task—image inpainting—to pretrain models for brain MRI segmentation. A multitask pretraining framework jointly optimizes both objectives, yielding representations that outperform single‑task pretraining and training from scratch on three segmentation benchmarks (multiple sclerosis lesions, ischemic stroke lesions, and cortical structures). The study demonstrates that integrating domain‑specific and general self‑supervised tasks benefits the development of generalizable neuroimaging foundation models.
By Tasneem Nasser, Susanne Schmid, Roberto Souza, Naser El-Sheimy
arXiv:2608. 19666v1 Announce Type: new Abstract: Deep learning-based whole-body PET-CT lesion segmentation can support cancer staging, treatment planning, and response assessment, but generalization is limited by scarce annotations and domain shifts.
By Bashirul Azam Biswas, Amartya Bhattacharya, Biratal Raj Wagle, Matthew E. Maeder, James B. Yu, Indrani Bhattacharya