arXiv AI By Pietro Miotto, Lucia Mellini, Tommaso Marzi, Cesare Alippi, Elena Casiraghi, Alberto Paccanaro, Giorgio Valentini, Mauricio Soto-Gomez

Hyperbolic Graph Representation Learning for Differential Diagnosis on Biomedical Knowledge Graphs

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The paper investigates hyperbolic graph representation learning applied to biomedical knowledge graphs for Mendelian-disease differential diagnosis. It shows that hyperbolic embeddings outperform Euclidean baselines on isolated ontology subgraphs while requiring fewer dimensions. In a link-prediction task, hyperbolic models rank candidate diseases for patients, indicating they can leverage hierarchical structure in heterogeneous patient-level graphs.

Machine-generated by The Flow from the publisher's headline and feed description — not written or checked by a human. The full article lives at arXiv AI.

arXiv AI
4d ago

Discovering Hierarchy-Grounded Domains with Adaptive Granularity for Clinical Domain Generalization

The paper introduces UdonCare, a hierarchy‑pruning method that iteratively partitions patients into latent domains using medical ontologies, aiming to improve domain generalization in clinical prediction tasks. It addresses challenges of missing domain labels and lack of clinical insight by discovering hierarchy‑grounded patient domains. Experiments on MIMIC‑III, MIMIC‑IV, and eICU datasets show UdonCare outperforms eight baseline methods across four prediction tasks with significant domain gaps.

By Pengfei Hu, Xiaoxue Han, Fei Wang, Yue Ning
arXiv AI
Aug 10

MolBioKG: Grounding Out-of-Graph Molecules in Biomedical Knowledge Graphs via Multi-Resolution Structural Anchoring

arXiv:2608. 06713v1 Announce Type: new Abstract: Biomedical knowledge graphs (KGs) accelerate drug discovery, but standard pipelines assume query molecules already exist as graph entities, leaving unregistered molecules disconnected.

By Yiming Zhang, Hikaru Shindo, Shuan Chen, Kaushalya Madhawa, Jun Jin Choong, Yuna Oikawa, Takashi Fujiwara, Keisuke Ozawa