HAPI-EP: Towards Hybrid, Adaptive, and Predictive Digital Twins of Cardiac Electrophysiology
arXiv:2606. 15637v1 Announce Type: new Abstract: A digital twin (DT) of a patient-specific heart offers significant potential in personalized medicine.
arXiv:2606. 06094v1 Announce Type: cross Abstract: Advances in computational modeling, neuroimaging, and artificial intelligence are revolutionizing the modeling of neurological disorders for improved diagnostics, prognosis, and treatment planning.
arXiv:2606. 15637v1 Announce Type: new Abstract: A digital twin (DT) of a patient-specific heart offers significant potential in personalized medicine.
The paper introduces a reverse spatio‑temporal disease progression model that reconstructs unobserved healthier anatomy from later diseased scans. It employs a two‑stage architecture: a frozen 3D vector‑quantised autoencoder creates a discrete latent space, and a Neural ODE learns continuous‑time dynamics, with a recurrent encoder initializing the latent state from reverse‑ordered observations. Experiments on a synthetic Morpho‑MNIST benchmark and longitudinal Alzheimer’s MRIs show the model can recover unseen prior states and outperform baseline methods in predicting healthy trajectories.
arXiv:2607. 15180v1 Announce Type: new Abstract: Ordinary differential equations (ODEs) are widely used to model dynamical systems in physics, biology, neuroscience, and physiology, but in many applications some equations of the dynamics are unknown and only a subset of the state variables are measured.
arXiv:2606. 19754v1 Announce Type: new Abstract: Partial differential equations (PDEs) play a central role in modeling complex physical, biological, and engineering systems.
The paper presents a differentiable hybrid modelling framework that combines a JAX finite volume population balance solver with learnable neural network components. This approach learns constitutive laws and initial conditions directly from experimental data, improving the fidelity of transport models in chemical engineering. The framework’s differentiability also enables optimisation of experimental settings for desired process outcomes.
arXiv:2607. 07425v1 Announce Type: cross Abstract: Many biological processes are governed by complex dynamical mechanisms that remain incompletely understood despite increasing volumes of experimental data.
arXiv:2608. 03927v1 Announce Type: new Abstract: Engineered Skeletal Muscle Tissues (ESMs) have become a key structure for biomedical disease modeling and pharmacological screening, yet their functional characterization often relies on simplistic metrics like peak force, discarding critical kinetic information.
arXiv:2606. 02145v1 Announce Type: new Abstract: Accurate prediction of polymerization dynamics is essential for process design, control, and optimization.
arXiv:2604. 07366v2 Announce Type: replace Abstract: Partial differential equations (PDEs) govern nearly every physical process in science and engineering, but solving them at scale remains prohibitively expensive.
The paper presents a differentiable hybrid modelling framework that combines a JAX finite volume population balance solver with neural network components to learn constitutive laws and initial conditions directly from experimental data. This approach addresses biases from hand‑picked models and the limitations of black‑box surrogates, enabling more accurate transport predictions. The framework’s differentiability also facilitates optimisation of experimental settings for desired process outcomes.
arXiv:2510. 09685v2 Announce Type: replace-cross Abstract: Deep learning has become a pivotal technology in fields such as computer vision, scientific computing, and dynamical systems, significantly advancing these disciplines.
arXiv:2607. 26490v1 Announce Type: cross Abstract: Physics-informed neural networks (PINNs) have emerged as a powerful paradigm for solving partial differential equations (PDEs), yet their performance heavily relies on the manual, trial-and-error engineering of neural representations, loss formulations, and optimization dynamics.