arXiv Machine Learning

Integrating Mechanistic and Data-Driven Models for Neurological Disorders through Differentiable Programming

arXiv:2606. 06094v1 Announce Type: cross Abstract: Advances in computational modeling, neuroimaging, and artificial intelligence are revolutionizing the modeling of neurological disorders for improved diagnostics, prognosis, and treatment planning.

arXiv Computer Vision
Sep 15

Reverse Spatio-Temporal Disease Progression Modelling

The paper introduces a reverse spatio‑temporal disease progression model that reconstructs unobserved healthier anatomy from later diseased scans. It employs a two‑stage architecture: a frozen 3D vector‑quantised autoencoder creates a discrete latent space, and a Neural ODE learns continuous‑time dynamics, with a recurrent encoder initializing the latent state from reverse‑ordered observations. Experiments on a synthetic Morpho‑MNIST benchmark and longitudinal Alzheimer’s MRIs show the model can recover unseen prior states and outperform baseline methods in predicting healthy trajectories.

By Ulugbek Shernazarov, Moucheng Xu, Inomjon Ramatov
arXiv Machine Learning
Jul 17

RTS Smoother-Guided Learning of Physics-Based Neural Differential Models

arXiv:2607. 15180v1 Announce Type: new Abstract: Ordinary differential equations (ODEs) are widely used to model dynamical systems in physics, biology, neuroscience, and physiology, but in many applications some equations of the dynamics are unknown and only a subset of the state variables are measured.

By Ahmet Demirkaya, Georgios Stratis, Tales Imbiriba, Zachary D. Danziger, Deniz Erdogmus
arXiv Machine Learning
Sep 4

Differentiable Hybrid Modelling for Learning and Optimising Chemical Transport Processes from Experimental Data

The paper presents a differentiable hybrid modelling framework that combines a JAX finite volume population balance solver with learnable neural network components. This approach learns constitutive laws and initial conditions directly from experimental data, improving the fidelity of transport models in chemical engineering. The framework’s differentiability also enables optimisation of experimental settings for desired process outcomes.

By Arthur Jessop, Mohammed Alsubeihi, Ben Moseley, Ashwin Kumar Rajagopalan
arXiv Machine Learning
Aug 5

A Physics-Flavored Transformer Network for Parametrizing Contraction Dynamics of Engineered Skeletal Muscle Tissues

arXiv:2608. 03927v1 Announce Type: new Abstract: Engineered Skeletal Muscle Tissues (ESMs) have become a key structure for biomedical disease modeling and pharmacological screening, yet their functional characterization often relies on simplistic metrics like peak force, discarding critical kinetic information.

By Mattias Luber, Timo Betz
Hugging Face Trending Papers
Sep 3

Differentiable Hybrid Modelling for Learning and Optimising Chemical Transport Processes from Experimental Data

The paper presents a differentiable hybrid modelling framework that combines a JAX finite volume population balance solver with neural network components to learn constitutive laws and initial conditions directly from experimental data. This approach addresses biases from hand‑picked models and the limitations of black‑box surrogates, enabling more accurate transport predictions. The framework’s differentiability also facilitates optimisation of experimental settings for desired process outcomes.

arXiv Machine Learning
Jul 30

EvoPINN: Agentic Discovery of Executable Algorithms for Physics-Informed Neural Networks

arXiv:2607. 26490v1 Announce Type: cross Abstract: Physics-informed neural networks (PINNs) have emerged as a powerful paradigm for solving partial differential equations (PDEs), yet their performance heavily relies on the manual, trial-and-error engineering of neural representations, loss formulations, and optimization dynamics.

By Peng Yin, Kai Li, Yifan Zhang, Jian Cheng