FPicker is a topology-guided framework for filament tracing in low‑signal Cryo‑EM images. It combines a center‑endpoint representation with an open‑curve evolution module to model non‑cyclic connectivity, overcoming limitations of pixel‑wise segmenters, box‑based detectors, sequential trackers, and traditional active contours. On simulated benchmarks, FPicker improves mean spatio‑angular precision by over 40% and reduces topological gap rates by more than 60% under extreme noise, and it achieves state‑of‑the‑art performance on real EMPIAR data after fine‑tuning.
By Tingyin Zhao, Mingtao Huang, Yuan Shen
TopoFuse introduces a topology-aware tri-planar fusion method for 3D cryo-electron tomography segmentation. It replaces traditional loss penalties with a differentiable projection operator that identifies and sparsely edits critical voxels to enforce specified topological constraints. The approach achieves a 54% reduction in Betti number error, a 4.6-point Dice improvement, and edits only 3.1% of voxels across three benchmarks.
By Rohit Kumar Salla, Neelesh Gupta, Xingjian Li, Min Xu
arXiv:2607. 05815v1 Announce Type: new Abstract: The Minkowski functionals of a field's excursion sets -- area, boundary measure, and Euler characteristic -- describe its level-set morphology; the Euler characteristic is the cheapest handle on topology.
By Gunner Levi Howe
arXiv:2606. 10255v1 Announce Type: cross Abstract: Cryo-electron tomography (cryoET) has emerged as a powerful tool in structural and cellular biology by enabling direct visualization of macromolecular structures within intact cells, thereby linking molecular architecture to cellular organization in a native context.
By Jonathan Schwartz, Utz Heinrich Ermel, C. Braxton Owens, Zhuowen Zhao, Ariana Peck, Gus L. W. Hart, Grant J. Jensen, Bridget Carragher, Dari Kimanius
arXiv:2609.09832v1 Announce Type: new
Abstract: Recent advances in high-resolution fluorescence and electron microscopy have enabled nanoscale imaging across increasingly large brain volumes, but the...
By Jiayi Ding, Hu Zhao
arXiv:2608.30768v1 Announce Type: new
Abstract: Automatic neuron reconstruction from light microscopy images is a central problem in computational neuroanatomy. While recent methods have achieved enc...
By Zekang Yang, Jiamin Li, Zhenghua Li, Jiaqi Fan, Zengcai Guo, Xiaolin Hu