Evidence-Grounded Agentic Formulation Development in an Autonomous Laboratory

The paper introduces Andromeda 2, an agentic system that uses structured in‑house experimental evidence to design and run successive batches of self‑emulsifying drug delivery systems (SEDDS). In a miniaturized automated lab, Andromeda 2 outperformed its predecessor Andromeda 1 and a traditional design‑of‑experiments campaign in developing paclitaxel formulations, achieving a 50 % hit rate versus 17 % and 2 % respectively, and identifying 12 formulations meeting all target product profile objectives. The system’s use of evidence‑grounded reasoning increased mean AUC by 34 % and produced a formulation with a 19 % w/w paclitaxel loading, roughly 3.3‑fold higher than a published benchmark.

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• agents
• benchmarks