arXiv:2606. 28363v1 Announce Type: cross Abstract: Objective: To describe the architecture and design rationale of meta-pipe, an open-source large language model (LLM)-agent pipeline that integrates the complete systematic review and meta-analysis (SR/MA) workflow -- from literature search through statistical analysis, manuscript generation, and quality assurance -- with mandatory human oversight at critical decision points.
By Hsieh-Ting Lin, Jiunn-Tyng Yeh
arXiv:2605. 06177v2 Announce Type: replace Abstract: Reproducing and comparing deep research agents today is hard: the same backbone evaluated on the same benchmark can report different accuracies across papers because the harness and tool registry differ, and integrating a new model into a comparable evaluation surface costs weeks of model-specific engineering.
By Jinge Wu, Hongjian Zhou, Mingde Zeng, Jiayuan Zhu, Junde Wu, Jiazhen Pan, Ayush Noori, Sean Wu, Honghan Wu, Fenglin Liu, David A. Clifton
arXiv:2609.21859v1 Announce Type: new
Abstract: Nearly 90% of drugs entering clinical development ultimately fail, despite billions of dollars in investment. Pharmaceutical companies therefore rely o...
By Jiacheng Lin, Zifeng Wang, Zheng Chen, Erick Scott, Ziwei Yang, Fanyang Yu, Sheng Zhong, Jimeng Sun
The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.
By Yinzhu Chen, Abdine Maiga, Hossein A. Rahmani, Emine Yilmaz
arXiv:2608.23397v1 Announce Type: new
Abstract: Interactive clinical agents must gather decisive evidence and convert it into grounded actions under partial observability. A correct final diagnosis a...
By Ruoyu Wu, Shenfu Xie, Yinqian Sun, Haibo Tong, Feifei Zhao
arXiv:2607. 22555v1 Announce Type: new Abstract: Medical diagnosis is a multi-stage process: extract facts, consult knowledge, generate a differential analysis, and select the best diagnosis with explanations.
By Mahmood Bayeshi, Veysel Kocaman, Muhammed Ali Naqvi, Yigit Gul, David Talby
arXiv:2608.28974v1 Announce Type: new
Abstract: Clinically relevant oncology information is distributed across heterogeneous, longitudinal documentation, creating substantial abstraction burden and r...
By Daniel Kang, Michelle Hu, Soorya Ram Shimgekar, Shayan Vassef, Yufan Wang, Anit Kumar Sahu, Munmun De Choudhury, Vedant Das Swain, Christian Poellabauer, Li Yan Khor, Koustuv Saha, Robert Wojciechowski, Elliot Kidd, Piyum Zonooz, Navin Kumar
The study evaluates a standalone large language model (LLM) versus a four‑step agentic pipeline for generating explanations of ICU mortality predictions on the eICU Demo dataset. XGBoost achieved an AUROC of 0.855 and an AUPRC of 0.332. In a 38‑case explanation subset, the standalone LLM produced one explanation with outcome leakage, while the agentic pipeline produced none; among 14 overlapping SHAP cases, the standalone LLM had higher SHAP alignment and direction consistency, whereas the agentic pipeline showed better guideline grounding, value specificity, and plausibility.
By Di Zhu, Chen Xie, Haoyun Zhang, Zihan Wei, Ziwei Wang, Jiazhao Shi, Ziyu Wang, Qiyang Xie
Background: Disease severity is a multidimensional construct difficult to capture with rule-based approaches in Electronic Healthcare Records (EHR). Agentic large language model (LLM) systems could synthesise clinical evidence and reason over EHRs, but remain unevaluated for this task.
arXiv:2606. 19345v1 Announce Type: cross Abstract: The rapid increase in scientific publications leads to the fact that manual study screening in systematic literature reviews (SLRs) is increasingly resource consuming, inefficient, and inconsistent.
By Zhyar Rzgar K. Rostam, M\'arta P\'entek, J\'anos Tibor Czere, Zsombor Zrubka, L\'aszl\'o Gul\'acsi, G\'abor Kert\'esz
The paper introduces Debate-Mixture-of-Agents (DMoA), a multi‑agent framework that structures role‑based interactions to mimic iterative diagnostic reasoning in clinical settings. Evaluated on 297 rare disease cases and 1,719 challenging cases, DMoA outperformed a GPT‑4o baseline, improving most likely diagnosis accuracy by 10.21 percentage points and safety rate by 11.36 percentage points. Ablation studies and further analyses revealed that these gains stem from the structured workflow rather than merely adding more models or longer outputs, and that performance benefits are influenced by the chosen structure, base model strength, and token budget.
By Chang Xia, Leilei Ouyang, Huimin Wang, Yong Zhao, Kang Li
arXiv:2602. 19502v2 Announce Type: replace Abstract: Agentic AI systems are increasingly capable of autonomous data science workflows, yet clinical prediction tasks demand domain expertise that purely automated approaches struggle to provide.
By Lalitha Pranathi Pulavarthy, Raajitha Muthyala, Aravind V Kuruvikkattil, Zhenan Yin, Rashmita Kudamala, Saptarshi Purkayastha