arXiv AI By Jaime Yan

GxP-Agent: Process-DAG Topology for Reliable Clinical Trial Programming with LLM Agents

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GxP-Agent is a multi‑agent system that transforms clinical trial protocols into CDISC‑compliant datasets by encoding the regulatory workflow as a directed acyclic graph (DAG). Each node in the DAG represents a domain‑specific task executed by a worker agent with specialized skill context, validation gates, and conditional retry logic. On the CDISC‑Bench benchmark, GxP-Agent with Claude Sonnet 4.6 achieved a perfect 100 % structural match for 49 variables across 254 records, outperforming single‑agent and flat multi‑agent baselines and enabling weaker models like GPT‑4.1 to reach 59.2 % under the same DAG.

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