arXiv AI By Yangmin Huang, Shu Quan, He Geng, Xin Ye, Qianyun Du, Zhiyang He, Jiaxue Hu, Xiaodong Tao

Dense Clinical Contrasts Enhance Medical Knowledge Updating in Large Language Models

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arXiv AI
Sep 30

TRACE: Deployable Tree-Relational Structure Enhancement for Oncology LLMs

TRACE is a deployable framework that enhances oncology language models by separating offline structure learning from online inference. It organizes oncology concepts and relations into an updatable tree‑relational structure, refines it with LM‑loss evidence, and retrieves compact prompt evidence during inference. The approach improves performance on ten classification tasks and a QA benchmark, outperforms vanilla RAG and generic GraphRAG, and provides interpretable evidence paths aligned with clinical reasoning.

By Jizheng Lai, Yingyun Li, Ying Qin, Haiyang Qian
arXiv AI
Jul 24

A Knowledge-Injection Framework for Zero-Shot Adaptation of LLMs to Delirium Prediction

arXiv:2607. 20453v1 Announce Type: cross Abstract: Large language models show promise for clinical prediction, but zero-shot performance on specialized tasks is limited by incomplete domain knowledge, especially for smaller locally deployable models.

By Jessica Sena, Shesadree Priyadarshani, Miguel Contreras, Bharat Gandhi, Scott Siegel, Subhash Nerella, Parisa Rashidi
arXiv AI
Aug 19

Foundation Agents Meet Agentic Deep Research: Evidence-Grounded Clinical Code Forecasting

The paper introduces ICD-Deepresearch, a workflow that combines foundation models for electronic health records (EHR) and language models with medical search and ICD dictionaries to forecast future ICD codes for upcoming clinical encounters. It evaluates candidate code transitions by linking patient evidence, external clinical relations, and exact code semantics within a fixed top‑K budget, using SparseEHR for initial priors, GPT‑5 for complementary forecasts, and a final selection step that validates, deduplicates, and ranks candidates. The method achieves patient‑averaged precision/recall of 24.60/35.09% on MIMIC‑III and 25.14/48.32% on MIMIC‑IV, with physicians rating 51–68% of its retrieved documents as useful, outperforming standalone GPT‑5 web search and Medical Deep Research.

By Junda Wang, Meysam Ghaffari, Akshat Choube, Mohsen Sharifi Renani, Hong Yu, Carlos Morato