Deep Learning for Biopsy-Free Subtyping of Basal Cell Carcinoma from Dermatoscopic Images
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Accurate dermatological diagnosis naturally necessitates equitable performance across diverse populations, yet a systematic lack of expertly annotated images, especially for underrepresented skin tones and rare diseases, impedes progress toward measurably fair methods. We introduce cgDDI (Controllable Generation of Diverse Dermatological Imagery), a hybrid framework that (1) synthesizes realistic healthy skin samples without disturbing other input properties, (2) maps single-sample rare lesions onto novel skin-tones and locations non-parametrically, and (3) allows for efficient parametric generation with as few as 10 training samples.
The study compares five pre‑trained convolutional neural networks—ResNet50, VGG16, VGG19, MobileNet, and InceptionV3—for melanoma detection using dermatoscopic and histopathological image datasets. Accuracy varied across models and modalities, with ResNet50 achieving the highest scores (84% on HAM10000 and 83% on CR‑AI4SkIN) and InceptionV3 the lowest (71% on ISIC 2018). The results show that a model’s performance on dermatoscopic images does not necessarily predict its performance on histopathological images.
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The paper evaluates how well generalist and dermatology-specific machine learning models perform on diverse skin lesion datasets, including dermoscopic images and smartphone photographs. It benchmarks a range of architectures—general-purpose vision-language models, foundation models, and task-specific dermatology classifiers—under conditions of distribution shift, modality change, and demographic variability. The study quantifies the performance gap between current state‑of‑the‑art models and the robustness needed for safe, equitable clinical deployment.
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