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Domain Elastic Transform (DET) is a grid‑free, probabilistic framework that jointly aligns geometry and high‑dimensional vector‑valued functions on irregular sparse manifolds, such as those found in spatial transcriptomics. By treating data as functions rather than voxelized images, DET performs unsupervised, scalable registration through sampled point alignment and displacement interpolation, guided by a joint spatial‑functional Bayesian likelihood. Evaluations on MERFISH mouse‑brain slices and Stereo‑seq mouse‑embryo atlases show DET achieving superior spatial overlap and topology compared to existing pipelines, with an accelerated variant delivering high label‑transfer accuracy.
The growing number of medical vision foundation models highlights the need for effective model selection. However, mainstream selection methods rely on exhaustive fine-tuning, which is computationally expensive.
arXiv:2609.15669v1 Announce Type: cross Abstract: Multimodal image registration is a key component of many clinical workflows, yet it remains challenging because corresponding anatomical structures o...
The paper introduces a geometry‑guided sampling operator that directs feature sampling rather than altering convolution kernels in 3D encoder‑decoder networks. By predicting local orientations and bounded step sizes, the operator samples symmetrically around each voxel, generating compact geometric and boundary cues that improve fine‑structure segmentation. Replacing stride‑1 and stride‑2 operations in a 3D U‑Net yields consistent gains on BraTS, MSD Hepatic Vessel, and TDSC‑ABUS datasets, with better boundary metrics and fewer parameters, and the operator can be integrated into other backbones without architectural changes.
The paper introduces a Geometric-to-Semantic Spherical Transfer Learning framework for labeling cortical sulci on brain surfaces. It first pre‑trains a spherical encoder on ~30,000 unlabeled UK Biobank subjects using only curvature and depth, then injects sulcal fundi lines as a soft‑initialized Topological Prior Injector to bridge the geometric‑semantic gap. Experiments show the method surpasses fully supervised baselines, achieving a mean Dice score of 0.77 and delivering the largest gains on variable and tertiary sulci.
arXiv:2510. 24342v2 Announce Type: replace Abstract: Prior brain-AI alignment studies are typically constrained by specific inputs and tasks, limiting their ability to capture organizational properties across models with different modalities.