Beyond Single-Pathogen Forecasts: Predicting Shared Respiratory Hospital Burden from Influenza, COVID-19, and RSV
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arXiv:2606. 19560v1 Announce Type: new Abstract: Seasonal influenza infects millions of people and causes substantial morbidity and mortality in the United States each year, making accurate short-term forecasting a core public-health need.
The paper introduces Empirical Research Assistance (ERA), an autonomous system that employs Large Language Model‑guided tree search to create, evaluate, and refine executable forecasting software for infectious diseases. In a real‑time evaluation during the 2025‑26 U.S. respiratory season, ERA produced diverse models for influenza, COVID‑19, and RSV, and an ensemble of these models outperformed the CDC’s gold‑standard forecast ensembles across all three pathogens. ERA also demonstrated robustness in data‑scarce RSV scenarios and showed that higher‑tier language models and specific optimization metrics can improve forecast accuracy.
arXiv:2608. 06671v1 Announce Type: new Abstract: Wastewater-based surveillance is an effective tool for disease monitoring and can provide early warning of outbreaks.
arXiv:2608.20406v1 Announce Type: new Abstract: Public health forecasts must respond to abrupt changes in surveillance data without over-extrapolating noise, reporting artifacts, or temporary trends....
arXiv:2601. 20771v2 Announce Type: replace-cross Abstract: Accurate forecasting of infectious disease incidence is critical for public health planning and timely intervention.
arXiv:2511. 23276v2 Announce Type: replace Abstract: Effective HFMD surveillance requires forecasts capturing both time-series patterns and contextual drivers such as school calendars, weather, and policy or surveillance reports.