Pix2Rep-v2 is a self‑supervised learning framework that learns pixel‑ and voxel‑level representations for dense medical imaging tasks, using a redundancy‑reduction objective and equivariance principles to scale to 3D and wide field‑of‑view data. The method is evaluated on four datasets across multiple modalities, tasks, and backbones, demonstrating higher data‑efficiency in few‑shot scenarios and competitive performance, such as a +9.3 Dice point improvement in one‑shot segmentation on the M&Ms‑2 dataset. An in‑context dense prototype approach is also proposed, eliminating the need for downstream training.
By S. Sifaoui, E. Angelini, S. Toupin, T. Pezel, L. Le Folgoc
DALE-CT introduces depth‑aware 2D slice encoders that learn an anatomical world model of chest CT scans without 3D or positional supervision. By sampling self‑supervised views across a physical $z$‑axis slab, the encoder captures how anatomy changes between neighboring slices, enabling it to recover slice ordering and distinguish slices by anatomy alone. The model, trained on a large 287k‑scan corpus, achieves state‑of‑the‑art performance on CT‑RATE and is released with full code and evaluation tools.
By Evan W. Damron, Mahmut S. Gokmen, Mitchell A. Klusty, Caroline N. Leach, Emily B. Collier, V. K. Cody Bumgardner
arXiv:2609.25850v1 Announce Type: new
Abstract: Deep learning performance generally improves with increasing training data, yet this scaling is fundamentally constrained by annotation cost in large-s...
By Xiaofei Du, Lei Zhang, Shuyu Yan, Manning Wang, Zhijian Song
The paper presents a 3D foundation model for light sheet fluorescence microscopy (LSM) that is pretrained on a large curated set of 3D images from various organisms, stains, and imaging protocols. By jointly optimizing for masked reconstruction and image‑text alignment, the model learns transferable volumetric representations that dramatically reduce the need for annotated data. The pretrained backbone enables efficient few‑shot adaptation to downstream tasks such as segmentation, classification, and deblurring, consistently outperforming baselines according to standard metrics and expert evaluation.
By Adina Scheinfeld, Haotan Zhang, Shang Mu, Rudolf L. M. van Herten, Lucas Stoffl, Ali Erturk, Zhuhao Wu, Johannes C. Paetzold
arXiv:2606. 03888v1 Announce Type: cross Abstract: Self-supervised learning has enabled large-scale pre-training on 2D natural images, producing general-purpose visual representations that transfer effectively across tasks.
By Ioannis Gatopoulos, Nicolas K\"anzig, Sebastian Ot\'alora, Fei Tang
DART is a new RGB‑D pretraining method for surgical vision foundation models that incorporates pseudo‑labeled depth maps as a pixel‑space reconstruction target during training. By adding a depth reconstruction head to DINOv2’s masked iBOT framework, DART improves representation quality without affecting downstream RGB‑only fine‑tuning or inference. Across eight surgical benchmarks—including segmentation, depth estimation, and image‑level recognition—DART outperforms both natural‑image and in‑domain baselines, demonstrating that geometric pseudo‑labels can strengthen foundation model pretraining without extra labels or inference cost.
By John J. Han, Adam Schmidt, Muhammad Abdullah Jamal, Jie Ying Wu, Omid Mohareri
arXiv:2510. 15042v3 Announce Type: replace-cross Abstract: In the 3D medical image domain, vision-language pre-training is used to create vision-language encoders (VLEs) that can support radiologists by retrieving patients with similar abnormalities, predicting likelihoods of abnormality, or, with downstream adaptation, generating radiological reports.
By Tassilo Wald, Ibrahim Ethem Hamamci, Yuan Gao, Sam Bond-Taylor, Harshita Sharma, Maximilian Ilse, Cynthia Lo, Olesya Melnichenko, Anton Schwaighofer, Noel C. F. Codella, Maria Teodora Wetscherek, Klaus H. Maier-Hein, Panagiotis Korfiatis, Valentina Salvatelli, Javier Alvarez-Valle, Fernando P\'erez-Garc\'ia
arXiv:2607. 23343v1 Announce Type: cross Abstract: Intraoperative 2D/3D registration aligns preoperative CT volumes with intraoperative X-ray or fluoroscopic images and is essential for image-guided interventions.
By Minheng Chen, Youyong Kong
arXiv:2605. 23995v4 Announce Type: replace-cross Abstract: Self-supervised learning (SSL) is increasingly used in medical image analysis to reduce dependence on costly expert annotations by learning transferable representations from unlabeled data.
By Chathura Wimalasiri, Kishor Nandakishor, Marimuthu Palaniswami
The paper introduces a geometry‑guided sampling operator that directs feature sampling rather than altering convolution kernels in 3D encoder‑decoder networks. By predicting local orientations and bounded step sizes, the operator samples symmetrically around each voxel, generating compact geometric and boundary cues that improve fine‑structure segmentation. Replacing stride‑1 and stride‑2 operations in a 3D U‑Net yields consistent gains on BraTS, MSD Hepatic Vessel, and TDSC‑ABUS datasets, with better boundary metrics and fewer parameters, and the operator can be integrated into other backbones without architectural changes.
By Sizhe Wang, Himashi Peiris, Zhaolin Chen
arXiv:2608. 08135v1 Announce Type: cross Abstract: Cross-modality medical image translation can reduce the burden of multi-modal acquisitions, yet the field remains constrained by two coupled limitations: methods operate on 2D slices or 3D patches rather than whole volumes, and train a separate model for each translation task.
By Daniele Molino, Alessio Zoboli, Camillo Maria Caruso, Valerio Guarrasi, Paolo Soda
arXiv:2603. 18846v3 Announce Type: replace-cross Abstract: Foundation models are used to extract transferable representations from large amounts of unlabeled data, typically via self-supervised learning (SSL).
By Samuel Ofosu Mensah, Camila Roa, Kerol Djoumessi, Philipp Berens