arXiv AI

Teaching LLMs How ICU Physicians Approach Clinical Reasoning Through OMOP-Aligned Retrieval Improves Reasoning Across Clinical Domains

arXiv AI

Jul 21

Enhancing LLMs' Clinical Reasoning with Real-World Data from a Nationwide Sepsis Registry

arXiv:2505. 02722v2 Announce Type: replace Abstract: Although large language models (LLMs) have demonstrated impressive reasoning capabilities across general domains, their effectiveness in real-world clinical practice remains limited.

By Junu Kim, Chaeeun Shim, Sungjin Park, Su Yeon Lee, Gee Young Suh, Chae-Man Lim, Seong Jin Choi, Song Mi Moon, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Sejoong Kim, Chami Im, Dong-Wan Kang, Yong Soo Kim, Hee-Joon Bae, Sung Yoon Lim, Han-Gil Jeong, Edward Choi

llms reinforcement-learning fine-tuning safety

arXiv AI

Jul 10

Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning

arXiv:2607. 07761v1 Announce Type: new Abstract: Large language models (LLMs) have emerged as important tools in healthcare, showing growing potential for clinical reasoning and patient care.

By Qi Peng, Jiatong Li, Sirui Huang, Yiyang Jiang, Kaisong Gong, Ronger Ding, Shijie Ye, Changmeng Zheng, Yi Cai, Xiaobo Yang, Jin Huang, Xiao-Yong Wei, Qing Li

llms benchmarks safety

arXiv Computer Vision

1d ago

Sparse Multi-Stage Expert-Agent Routing for Complex Clinical Reasoning

arXiv:2608.21948v1 Announce Type: new Abstract: Complex clinical reasoning requires models to update diagnostic hypotheses as new evidence emerges and to coordinate different medical specialities und...

By Sike Xiang, Shuang Chen, Qian sun, Jia Cheng, Yusi Wei, Amir Atapour-Abarghouei

llms agents

arXiv AI

2d ago

KREL: Automatic Medical Coding via Knowledge-Guided Reasoning over Clinical Evidence with LLMs

arXiv:2608.20887v1 Announce Type: cross Abstract: Automatic Medical Coding (AMC), which assigns standardized International Classification of Diseases (ICD) codes to clinical notes, is essential for m...

By Xubin Chen, Yipeng Zhou, Wen Sun, Chengkai Huang, Xiaoming Fu, Quan Z. Sheng

llms benchmarks safety

arXiv Machine Learning

Jun 2

OncoReason: Structuring Clinical Reasoning in LLMs for Robust and Interpretable Survival Prediction

arXiv:2510. 17532v2 Announce Type: replace-cross Abstract: Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data.

By Raghu Vamshi Hemadri, Geetha Krishna Guruju, Kristi Topollai, Anna Ewa Choromanska

llms nlp reinforcement-learning fine-tuning benchmarks safety

arXiv Machine Learning

Jun 8

GraphWalker: Patient Analogy Meets Information Gain for Clinical Reasoning with Large Language Models

arXiv:2604. 06684v2 Announce Type: replace Abstract: Clinical reasoning over electronic health records (EHRs) is a fundamental yet challenging task in modern healthcare.

By Yue Fang, Weibin Liao, Yuxin Guo, Jiaran Gao, Hongxin Ding, Jinyang Zhang, Xinke Jiang, Zhibang Yang, Junfeng Zhao, Yasha Wang, Liantao Ma

llms agents benchmarks

arXiv AI

Jun 9

From Conflict to Consensus: Boosting Medical Reasoning via Multi-Round Agentic RAG

arXiv:2603. 03292v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields.

By Wenhao Wu, Zhentao Tang, Yafu Li, Shixiong Kai, Mingxuan Yuan, Zhenhong Sun, Chunlin Chen, Zhi Wang

llms rag agents reinforcement-learning benchmarks safety

arXiv AI

Jul 7

Reinforcement Learning for Evidence-Seeking Diagnostic Reasoning with Large Language Models

arXiv:2607. 02983v1 Announce Type: new Abstract: Recent reasoning-centric Large Language Models (LLMs) have made significant strides, yet they predominantly operate on a passive-inference pattern that assumes complete information.

By Shengyi Hua, Kangzhe Hu, Conghui He, Xiaofan Zhang, Shaoting Zhang

llms rag agents reinforcement-learning

arXiv AI

Aug 18

DiagnosisArena: Benchmarking Diagnostic Reasoning for Large Language Models

arXiv:2505. 14107v5 Announce Type: replace-cross Abstract: The emergence of groundbreaking large language models capable of performing complex reasoning tasks holds significant promise for addressing various scientific challenges, including those arising in complex clinical scenarios.

By Yakun Zhu, Zhongzhen Huang, Linjie Mu, Yutong Huang, Wei Nie, Jiaji Liu, Shaoting Zhang, Pengfei Liu, Xiaofan Zhang

llms benchmarks

arXiv AI

Jul 2

RareDxR1: Autonomous Medical Reasoning for Rare Disease Diagnosis Beyond Human Annotation

arXiv:2607. 00147v1 Announce Type: new Abstract: Rare disease differential diagnosis is a critical yet arduous clinical task, requiring physicians to identify precise phenotypes from complex, unstructured patient symptoms and execute intricate reasoning within a vast search space.

By Deyang Jiang, Haoran Wu, Ziyi Wang, Yiming Rong, Yunlong Zhao, Ye Jin, Bo Xu

llms rag agents reinforcement-learning benchmarks

arXiv AI

Jun 30

An AI agent for treatment reasoning over a biomedical tool universe

arXiv:2606. 28692v1 Announce Type: new Abstract: Treatment reasoning underpins every therapeutic decision, integrating disease context, comorbidities, medications, contraindications, and evolving biomedical knowledge to select an appropriate therapy.

By Shanghua Gao, Ayush Noori, Richard Zhu, Curtis Ginder, Zhenglun Kong, Xiaorui Su, Justin Kauffman, Benjamin S. Glicksberg, Joshua Lampert, Ankit Sakhuja, Ashwin Sawant, ATHENA-R1 Evaluation Consortium, David A. Clifton, Noa Dagan, Ran Balicer, Marinka Zitnik

llms agents reinforcement-learning fine-tuning benchmarks

arXiv AI

Jun 30

Clinical Reasoning Graphs: Structured Evaluation of LLM Diagnostic Reasoning Reveals Competence Without Consistency

arXiv:2606. 29876v1 Announce Type: cross Abstract: Modern large language models (LLMs) reach 60-70% diagnostic accuracy on complex clinical case benchmarks, but accuracy alone cannot distinguish stable clinically-grounded reasoning from pattern matching.

By Nisarg A. Patel (University of California, San Francisco)

llms benchmarks

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