The paper introduces Latent Drift, a generative forecasting framework that predicts slow-evolving neurodegenerative disease progression by learning changes in a compressed semantic representation rather than full-resolution anatomy. It addresses two failure modes—identity collapse and continuous interpolation trap—by removing pixel-level identity from the prediction target and applying Finite Scalar Quantization to suppress high-frequency nuisance fluctuations. Experiments on longitudinal 3D brain MRI demonstrate that Latent Drift outperforms diffusion and autoregressive transformer baselines in both generative fidelity and clinically relevant metrics.
By Yuxiang Feng, Juncheng Wang, Chao Xu, Wenlong Hou, Huihan Wang, Yijie Qian, Yang Liu, Baigui Sun, Yong Liu, Shujun Wang
arXiv:2512.08029v4 Announce Type: replace
Abstract: Clinical decision-making in oncology requires forecasting how disease evolves under treatment, yet most AI systems remain static predictors that ca...
By Tianxingjian Ding, Yuanhao Zou, Chen Chen, Mubarak Shah, Yu Tian
NeuroWeaver is an autonomous evolutionary agent that designs EEG analysis pipelines by framing pipeline engineering as a discrete constrained optimization problem solved with large language model–driven code generation. It uses a Domain‑Informed Subspace Initialization to keep the search within neuroscientifically plausible solutions and a Multi‑Objective Evolutionary Optimization to balance performance, novelty, and efficiency. On five diverse benchmarks, NeuroWeaver produces lightweight pipelines that outperform state‑of‑the‑art task‑specific methods and match or exceed large foundation models while using far fewer parameters.
By Guoan Wang, Shihao Yang, Feng Liu
arXiv:2606. 02228v1 Announce Type: cross Abstract: Predicting whether an individual with Alzheimer's disease will experience mild or severe disease progression is essential for personalized treatment.
By Clara Hoffmann, Nadja Klein
CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Models proposes a new framework to improve medical reasoning in LLMs. It introduces two key conditions—Causal Sufficiency and Proximal Learnability—to curate high-quality training trajectories, using agreement-based self-verification and dynamic entropy bounds. Experiments on medical multimodal and text-only benchmarks show that CARE outperforms competitors, reducing incorrect reasoning and enhancing training stability.
By Yucheng Zhou, Peng Luo, Qianning Wang, Chengzhong Xu, Jianbing Shen
arXiv:2602. 03901v5 Announce Type: replace Abstract: The pursuit of optimal trade-offs in high-dimensional search spaces under stringent computational constraints poses a fundamental challenge for contemporary multi-objective optimization.
By Rong Fu, Chunlei Meng, Haoyu Zhao, Kun Liu, JiaBao Dou, Youjin Wang, Simon James Fong
arXiv:2607. 24031v1 Announce Type: new Abstract: Brain-Machine Interfaces (BMIs), which link the brain to external devices, hold great potential in rehabilitation, human performance augmentation, and human-centered robotics.
By Jiyu Wei, Di Hong, Zhanjie Zhang, Dazhong Rong, Qinming He, Yueming Wang
ClinicalReTrial is a multi‑agent AI system that treats clinical trial protocol optimization as an iterative redesign problem on textual documents. It combines failure diagnosis, safety‑aware modifications, and candidate evaluation within a closed‑loop, reward‑driven framework, using a predictive model as a simulation environment for low‑cost, dense feedback. The system achieves a 56.7% conversion of failed protocols to predicted successes, with a 7.4% average success probability increase at a negligible cost, and its redesign patterns align with real‑world expert changes.
By Sixue Xing, Kerui Wu, Xuanye Xia, Haoyu He, Meng Jiang, Jintai Chen, Tianfan Fu
arXiv:2607. 12687v1 Announce Type: cross Abstract: LLMs can perform language-based quantitative prediction from unstructured inputs, but remain susceptible to hallucinations and overconfident errors, making it critical to know not only what a model predicts, but when its predictions can be trusted.
By Mehak Dhaliwal, Rasta Tadayon, Andong Hua, Haewon Jeong, Yao Qin
arXiv:2512. 08029v3 Announce Type: replace Abstract: Clinical decision-making in oncology requires predicting dynamic disease evolution, a task current static AI predictors cannot perform.
By Tianxingjian Ding, Yuanhao Zou, Chen Chen, Mubarak Shah, Yu Tian
arXiv:2604. 26170v2 Announce Type: replace Abstract: Adapting large language models (LLMs) to a targeted task efficiently and effectively remains a fundamental challenge.
By Ting-Wei Li, Sirui Chen, Jiaru Zou, Yingbing Huang, Tianxin Wei, Jingrui He, Hanghang Tong
arXiv:2605. 20468v2 Announce Type: replace Abstract: Effective medication management in Parkinson's Disease (PD) is challenging due to heterogeneous disease progression, variable patient response, and medication side effects.
By Ricardo Diaz-Rincon, Muxuan Liang, Adolfo Ramirez-Zamora, Benjamin Shickel