arXiv:2606. 10279v1 Announce Type: new Abstract: Supervised fine-tuning with synthetic rationale data is widely assumed to improve language model performance on clinical prediction tasks by teaching models not just what to predict but why.
Supervised fine-tuning with synthetic rationale data is widely assumed to improve language model performance on clinical prediction tasks by teaching models not just what to predict but why. We test this assumption on five-year Alzheimer's disease and related dementias (ADRD) prediction from longitudinal health histories.
The paper introduces a unified pre‑training framework for medical representations that incorporates hierarchical sub‑token aggregation, partial masking, and cross‑reference mechanisms to better capture the structure of medical codes. The resulting model outperforms existing BERT‑based approaches on pre‑training tasks and downstream clinical predictions, such as dementia onset and hospitalization. An in‑silico drug repositioning study for Alzheimer’s disease demonstrates the framework’s ability to rediscover known drugs and prioritize new hypotheses without external literature, establishing a workflow for hypothesis generation and prioritization based on observational data.
arXiv:2607. 22770v1 Announce Type: new Abstract: Although artificial intelligence (AI) has shown promising performance in several medical tasks, accurate dementia etiology diagnosis with AI remains challenging due to complex overlapping symptoms among diseases.
arXiv:2602. 11177v2 Announce Type: replace-cross Abstract: Reliable early detection of Alzheimer's disease (AD) is challenging, particularly due to the limited availability of labeled data.
arXiv:2606. 02228v1 Announce Type: cross Abstract: Predicting whether an individual with Alzheimer's disease will experience mild or severe disease progression is essential for personalized treatment.
arXiv:2510. 17532v2 Announce Type: replace-cross Abstract: Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data.
Supervised fine-tuning (SFT) on a small, high-quality set of long reasoning traces is an effective approach for eliciting strong reasoning capabilities in Large Language Models (LLMs). However, existing methods for curating high-quality SFT data rely heavily on strong reasoning models to filter examples based on diversity and difficulty, making the curation process costly while often yielding suboptimal data quality.
arXiv:2607. 08778v1 Announce Type: cross Abstract: Alzheimer's Disease (AD) is a complex neurodegenerative disorder that continues to impact millions of people worldwide.
arXiv:2607. 12687v1 Announce Type: cross Abstract: LLMs can perform language-based quantitative prediction from unstructured inputs, but remain susceptible to hallucinations and overconfident errors, making it critical to know not only what a model predicts, but when its predictions can be trusted.
arXiv:2606. 26797v1 Announce Type: new Abstract: Supervised fine-tuning (SFT) on a small, high-quality set of long reasoning traces is an effective approach for eliciting strong reasoning capabilities in Large Language Models (LLMs).
The paper discusses how large language models (LLMs) can be fine‑tuned with observational data to improve alignment with human preferences and business goals. It highlights that directly using such data can cause models to learn spurious correlations, and introduces DeconfoundLM, a method that removes known confounders from reward signals. Experiments show that DeconfoundLM better recovers causal relationships and outperforms baseline methods by over 16% in objective score when confounding is present.
arXiv:2606. 07237v1 Announce Type: cross Abstract: Large Language Models (LLMs) are increasingly used in healthcare for tasks such as clinical question answering, diagnosis support, and report summarization.