arXiv:2602. 11177v2 Announce Type: replace-cross Abstract: Reliable early detection of Alzheimer's disease (AD) is challenging, particularly due to the limited availability of labeled data.
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The study examines how speech preprocessing—such as enhancement, sample selection, and demographic balancing—affects Alzheimer’s disease detection models that use the Pitt Corpus. Experiments reveal that while speech‑enhanced datasets boost in‑domain accuracy, they diminish cross‑dataset robustness and introduce class imbalance and prediction shifts, even when training and testing enhancements are matched. Large audio‑language models show similar sensitivity, indicating that cleaner speech does not guarantee better real‑world performance.
Speech-based Alzheimer's disease (AD) detection increasingly relies on speech-enhanced and curated versions of the Pitt Corpus, where speech enhancement, sample selection, and demographic balancing ar...
The paper examines why speech‑based screening for Alzheimer’s disease fails to generalize across different languages, tasks, and recording protocols. Using a leave‑one‑corpus‑out evaluation on four datasets, it finds that 59 of 70 interpretable speech features show conflicting patterns between healthy controls and cognitive risk groups, with pause, silence, and speech rate being highly protocol‑sensitive. The authors propose a fusion method that combines XLM‑R text baseline scores with evidence anchors, improving mean speaker AUC to 0.785 and worst‑case AUC to 0.615, and emphasize the importance of auditing feature transferability and reporting worst‑case domain robustness.
The development of multilingual Alzheimer's Disease Dementia (AD) detection models presents significant challenges due to the resource-intensive and time-consuming nature of language-specific model training. We propose a novel solution using cross-language training to detect AD in languages beyond those used for model training.
The paper investigates the interpretability of Domain-Adapted Prompt-based Fine-tuning (DAPF) models for dementia detection from spoken language. Using probing and analysis techniques, the authors find that DAPF achieves strong overall performance (accuracy = 0.83, macro‑F1 = 0.83) and that the diagnosis is most recoverable from its [MASK] representation. However, token‑level explanations derived from DAPF are largely driven by language‑task vocabulary, discourse markers, and transcription artifacts, and perturbation tests reveal weak or negative effects, indicating that the masked‑token interface captures diagnosis information without providing faithful token‑level explanations.
arXiv:2603. 13673v2 Announce Type: replace Abstract: Accurate extraction of Alzheimer's Disease and Related Dementias (ADRD) phenotypes from electronic health records (EHR) is critical for early-stage detection and disease staging.