The study benchmarks active spot selection methods against random sampling for spatial transcriptomics, focusing on cost‑efficient data acquisition. Using two public cohorts, the authors simulate multi‑round selection with uncertainty‑based (MC‑dropout, TOD) and diversity‑based (CoreSet, TypiClust) strategies, evaluating performance at 5%, 10%, 30%, and 50% of the spot pool. Results show that none of the active strategies consistently outperforms random sampling across all budgets or evaluation metrics, with performance varying by dataset and metric.
arXiv:2608. 03145v1 Announce Type: new Abstract: Deep learning models can predict cancer recurrence from H&E stained slides, but the localized molecular states underlying these predictions remain largely obscured.
arXiv:2607. 16250v1 Announce Type: cross Abstract: Estrogen Receptor (ER) status is a critical biomarker in breast cancer diagnosis, prognosis, and treatment selection.
arXiv:2511. 17605v2 Announce Type: replace Abstract: Clinical and gene-expression models predict breast cancer outcomes, but simple linear fusion ignores dependence between their risk scores.
arXiv:2608. 07609v1 Announce Type: cross Abstract: High-throughput screening (HTS) assays are central to early-stage drug discovery but are often limited by extreme data sparsity, as primary screens typically use only a single replicate per test substance.
arXiv:2410. 00945v2 Announce Type: replace-cross Abstract: Gene-expression profiling is widely used in research and central to many areas of precision oncology, but remains costly and not universally accessible.
arXiv:2606. 09898v2 Announce Type: replace Abstract: Cancer treatment involves decisions across multiple clinical outcomes, yet pathway-informed deep learning models are typically evaluated in isolation, making their relative benefits unclear.
Recent advances in pathology foundation models have enabled accurate prediction of spatial transcriptomics (ST) from routine H&E images. However, existing explainability methods for vision transformer...
CorrFlow is a new generative framework for predicting spatial transcriptomics from histology images. It explicitly models gene-gene interactions using an annealed masked flow matching strategy and a gene graph‑regularized optimization that incorporates prior knowledge from STRING and data‑driven co‑expression from WGCNA. Across 12 datasets, CorrFlow outperforms existing methods in average PCC and HPCC, producing more biologically coherent ST predictions.
arXiv:2606. 28659v1 Announce Type: cross Abstract: High-fidelity molecular docking simulations can produce biologically relevant estimates of epitope-receptor binding affinity but are computationally expensive and therefore limit the number of candidates that can be screened for vaccine design.
arXiv:2608.22785v1 Announce Type: new Abstract: Spatial multi-omics technologies jointly profile gene expression, surface proteins, and histology at each tissue spot, yet most spatial domain discover...
Spatial multi-omics technologies jointly profile gene expression, surface proteins, and histology at each tissue spot, yet most spatial domain discovery methods provide only cluster assignments, witho...
CaliPPer is a post‑hoc framework that calibrates and predicts the performance of binding‑prediction models by combining a multi‑chain Sample‑to‑Domain Distance (S2DD) metric with distance‑aware Bayesian recalibration. It operates at three resolutions—generalisability score, aggregate performance prediction, and per‑sample confidence—achieving strong distance‑performance correlations (|r| = 0.80–0.92) and low prediction errors for AUROC, AP, and F1. In retrospective analyses of five published studies, CaliPPer increased true discovery rates, improving AUROC by up to +0.20 on unseen epitopes and variants and raising confirmed neoantigen findings from 0/5 to 3/5.