arXiv AI

Medical Knowledge Simplification for Patients in the Era of LLMs: A Case Study on Diabetes

The paper presents MediClear, an LLM-based system that simplifies diabetes-related medical information for patients. By indexing public articles from Diabetes Australia, WHO, ADA, NIDDK, and AIHW in a Retrieval-Augmented Generation knowledge base, MediClear retrieves clinically grounded content and rewrites it into patient-friendly language. Evaluation shows the system consistently lowers reading levels to the recommended patient literacy range and receives high user satisfaction in a human study.

arXiv AI
Jun 6

Evaluating the Utility of Personal Health Records in Personalized Health AI

arXiv:2605. 18937v2 Announce Type: replace Abstract: Patient-managed Personal Health Records (PHRs) promises to empower patients to better understand their health; but information in the record is complex, potentially hindering insights.

By Rory Sayres, Kejia Chen, Ayush Jain, Matthew Thompson, Jonathan Richina, Xiang Yin, Jimmy Hu, Fan Zhang, Bob Lou, Mike Sanchez, Ines Mezerreg, Meredith Schreier, Hamsa Subramaniam, I-Ching Lee, Yugang Jia, Daniel Mcduff, Yossi Matias, Avinatan Hassidim, Dale Webster, Yun Liu, Jackie Barr, Quang Duong
arXiv Computation and Language
Sep 16

Enhancing Accessibility of Medical Texts through Large Language Model-Driven Plain Language Adaptation

The paper explores how Large Language Models (LLMs) such as GPT-4o-mini, Gemini-1.5-pro, and LLaMA can be used to automatically simplify complex medical texts into plain language, a process known as Plain Language Adaptation (PLA). It evaluates different prompting strategies, fine‑tunes models with QLoRA, and incorporates Mixture‑of‑Agents (MoA) techniques to improve adaptability and robustness. The results show that LLM‑driven PLA effectively makes healthcare information more comprehensible while preserving essential content.

By Ting-Wei Chang, Hen-Hsen Huang, Hsin-Hsi Chen
arXiv AI
Oct 15

Open Foundation Models in Healthcare: Challenges, Paradoxes, and Opportunities with GenAI Driven Personalized Prescription

The paper surveys open, non‑proprietary large language models (LLMs) and AI foundation models (AIFMs) for clinical use, presenting a taxonomy of current state‑of‑the‑art models. It empirically tests open‑weight LLMs on a personalized‑prescription task, finding that they match or surpass a proprietary baseline in overall suitability accuracy, especially when combined with Retrieval‑Augmented Generation (RAG). A subjective evaluation by blinded raters shows mixed effects of RAG on perceived suitability across multiple dimensions, and the authors discuss ethical risks and the need for responsible deployment.

By Mahdi Alkaeed, Sofiat Abioye, Adnan Qayyum, Yosra Magdi Mekki, Ilhem Berrou, Mohamed Abdallah, Ala Al-Fuqaha, Muhammad Bilal, Junaid Qadir
arXiv AI
Sep 4

MIRA: A Bilingual Benchmark for Medical Information Response Audit

MIRA is a bilingual benchmark that evaluates whether large language models (LLMs) provide consistent medical information across different user phrasings, languages, and health literacy levels. It contains 4,320 prompts derived from 60 medically reviewed low‑risk health questions and reveals that models tend to omit key information and offer fewer concrete next steps when responding to low health‑literacy signals, a phenomenon termed Differential Information Dilution (DID). A knowledge‑guided mitigation prompt can reduce this dilution for most models, notably improving Claude and Qwen.

By Mengyu Xu, Qiaoxin Yang, Qianqian Wang, Xiwei Dai, Weiyi Wu, Chongyang Gao
arXiv AI
Jul 9

Healthier LLMs: Retrieval-Augmented Generation for Public Health Question Answering

arXiv:2607. 06641v1 Announce Type: cross Abstract: Large language models (LLMs) achieve promising results on medical question answering benchmarks, yet their use in public health is constrained by hallucinations and the rapid evolution of official guidance.

By Felix Feldman, Joshua Harris, Timothy Laurence, Leo Loman, Ollie Higgins, Fan Grayson, Poonam Soma, Bethany Pace-Bonello, Michael Borowitz, Toby Nonnenmacher
arXiv AI
Sep 15

ClinAgent: A ReAct-Based Agent for Conversational Access to Clinical Trial Information

ClinAgent is a conversational system that uses a ReAct-based LLM agent to retrieve and synthesize clinical trial information from multiple sources such as ClinicalTrials.gov, PubMed, and a local dataset. The agent iteratively reasons over user queries, selects appropriate tools, and refines its actions to provide grounded, up-to-date responses in natural language across multi-turn interactions. Evaluation across three phases shows that DeepSeek (thinking mode) excels in planning quality while Gemini 3.0 Flash delivers the highest overall performance and expert ratings, demonstrating the promise of agentic AI for improving clinical trial data access.

By Antonino Vaccarella, Riccardo Cantini, Domenico Talia, Paolo Trunfio, Marianna Talia, Rosamaria Lappano, Marcello Maggiolini
arXiv Computation and Language
Sep 3

Improving Health Literacy through Lay Summarization of Radiological Reports: An Evaluation of BioNER and Retrieval-Augmented Generation

The paper examines how Retrieval-Augmented Generation (RAG) and Named Entity Recognition (NER) affect the quality of lay summaries of radiology reports. Using a framework that extracts clinically relevant findings via NER and grounds them with RAG, the authors evaluate few‑shot and fine‑tuned versions of Qwen and BioBART. Results show that NER consistently improves readability and overall quality, RAG alone offers no benefit and can introduce hallucinations, and the best performance comes from fine‑tuned BioBART with NER.

By Egecan \c{C}elik Evgin, \.Ilknur Karadeniz, Olcay Taner Y{\i}ld{\i}z